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Generalised mechanisms and associated examples of lncRNAs involved in cancer progression. Long noncoding RNAs act through a variety of mechanisms such as remodelling of chromatin (A), transcriptional co-activation or -repression (B), protein inhibition (C), as post- transcriptional modifiers (D) or...
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key re
We then sought to understand in how far the joint specific expression of HOX transcripts was involved in these site-specific gene expression changes. To this end, we silenced SF for HOXD10, HOXD11, HOXD13, and the long non-coding RNAs HOTAIR and HOTTIP, respectively. These HOX transcripts ...
For the many years, the central dogma of molecular biology has been that RNA functions mainly as an informational intermediate between a DNA sequence and its encoded protein. But one of the great surprises of modern biology was the discovery that protein-coding genes represent less than 2% of ...
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key re
Examples include newline (\n) for line breaks and tab (\t) for spacing. They play a vital role in text formatting, coding, and data transmission. Understanding and correctly utilizing these characters ensures well-structured code, readable text, and effective communication. Proper handling of ...
Two examples of relatively well-known schistosome non-coding RNAs are the hammerhead ribozyme motifs within the Sm-αand Sj-αSINE-like elements [27,28]. Ablastnsearch of the hammerhead ribozyme motif from theRfamdatabase resulted in ~38,500 candidates forS. mansoniin contrast to ~5,000 cand...
aNonexhaustive list of examples. It should be noted that some of these genetic loci are positive only in candidate gene studies but not in genome-wide association studies (GWASs). Molecular Psychiatry (2017), 497 – 511 From noncoding risk variations to molecular mechanisms X Xiao et al 506...
Among the few examples, expression of such non- this study. coding genes as HOTAIR, CDKN2B-AS (ANRIL), MALAT1, MEG3, NEAT1 and UCA1 has been shown to be associated with HNSC.22,23 Further, we evaluated whether high HPV16 expression is associated with certain anatomic sites and whether...