Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers James A. Oo, Timothy Warwick, Katalin Pálfi, Frederike Lam, Francois McNicoll, Cristian Prieto-Garcia, Stefan Günther, Can Cao, Yinuo Zhou, Alexey A. Gavrilov, Sergey V. Razin, Alfredo Cabrera...
S1b, red) of the 3’ terminus of the badA coding region was used as a negative control. No band shift was observed when Trp1 was added to this negative control coding region of the badA gene (lane 5). Further, unlabeled negative control coding region DNA was added in 200-fold excess...
www.nature.com/scientificreports OPEN ALS Along the Axons – Expression of Coding and Noncoding RNA Differs in Axons of ALS models received: 04 November 2016 accepted: 08 February 2017 Published: 16 March 2017 Nimrod Rotem1, Iddo Magen2, Ariel Ionescu1, Noga Gershoni-Emek1, Topaz...
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Long non-coding RNAs (lncRNAs) are critical regulators of numerous physiological processes and diseases, especially cancers. However, development of lncRNA-based therapies is limited because the mechanisms of many lncRNAs are obscure, and interactions with functional partners, including proteins, remain ...
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In specific embodiments, the one or more somatic gene mutations are in a coding region. In one aspect of such embodiments, the one or more somatic mutations result in an amino acid substitution. In another aspect of such embodiments, the one or more somatic gene mutations result in a prematu...