Association between non-coding transcript variant polymorphisms (rs3135499, rs3135500) of the NOD2 gene and the propensity to rheumatoid arthritis in the Iraqi populationRheumatoid arthritisNOD2Polymorphismrs31
Non-coding transcription cohesin CTCF compartmentalization T cell development lymphoma leukemia loop extrusion phase separation single-loop domain Introduction The differentiation of T cells is orchestrated in the thymus. Upon exposure to Delta-Notch signaling, early T cell progenitors (ETPs) differentiate ...
Surprisingly, we here show that a PIN1 transcript downregulates HIF-1α as a long non-coding RNA. Pin1-silencing siRNAs augmented the hypoxia-induced expression of HIF-1α, thereby upregulating the expression of HIF-1 target genes. However, the overexpression of Pin1 protein did not inhibit ...
Non-coding RNAs (ncRNAs) are a heterogeneous group of transcripts that, by definition, are not translated into proteins. Since their discovery, ncRNAs have emerged as important regulators of multiple biological functions across a range of cell types and
Noncoding RNAs (ncRNAs) are a large segment of the transcriptome that do not have apparent protein-coding roles, but they have been verified to play important roles in diverse biological processes, including disease pathogenesis. With the development of
perinatal lethal long non-coding RNA165;Pnky, pinky (also known aslnc-Pou3f2)448;Tug1, taurine upregulated gene 1 (refs.165,166,449)Upperhand, lncRNA upstream of theHand2cardiomyocyte transcription factor locus318;Xist, X-inactive-specific transcript450. Figure courtesy of Daniel Andergassen ...
Non-coding RNAs represent a significant proportion of the human genome. After having been considered as ‘junk’ for a long time, non-coding RNAs
Unraveling functional noncoding variants associated with complex diseases is still a great challenge. We present a novel algorithm, Prioritization And Functional Assessment (PAFA), that prioritizes and assesses the functionality of genetic variants by in
Long noncoding RNAs (lncRNAs) that may be used as cancer biomarkers and methods of diagnosing, prognosing and monitoring cancer including, but not limited to, cutaneous melanoma using said lncRNAs are provided herein. In some embodiments, the methods include steps of isolating one or more lncRNA...
Notwithstanding the significant progress made so far, there is still a long road ahead to accurately identify the true functional noncoding variants genetically associated with NBDs (see Outstanding questions). This process involves pinpointing the actual functional variant in the locus associated with ...