专辑征稿:non-coding RNA--生物医学类综合SCI期刊,审稿快速! 2020JZUS-BSpecial Issue onnon-coding RNA Scope Non-coding RNAs are a big class of RNAs, which were discovered in the last one decade. However, it plays steamily ...
Control ofgeneexpression by these small, noncodingRNAmolecules was first observed in 1993, when a team of scientists discovered a small, double-stranded RNA (dsRNA) in nematode (Caenorhabditis elegans) larvae that complemented the sense strand of a larger mRNA and bound to its 3'untranslated regi...
三、RNA pull-down:检测RNA结合蛋白与其靶RNA之间相互作用的主要实验手段之一。 左图是用LncRNA HIFCAR全长探针钓取细胞中与之结合的蛋白,右图是用LncRNA HIFCAR不同片段探针钓取细胞中与之结合的蛋白,然后用HIF-1a抗体检测pull-down产物蛋白,表明LncRNA HIFCAR与HIF-1a的结合区域不在501-1500。我公司在实验体系...
While basic similarities ingenetranscription exist between prokaryotes and eukaryotes—including the fact thatRNA polymerasebindsupstreamof the gene on itspromoterto initiate the process of transcription—multicellular eukaryotes control celldifferentiationthrough more complex and precise temporal and spatial regula...
参考文献:Erbao Zhang , Liang Han, Dandan Yin,et al. H3K27 acetylation activated-long non-coding RNA CCAT1 affects cell proliferation and migration by regulating SPRY4 and HOXB13 expression in esophageal squamous cell carcinoma[J].Nucleic Acids Research, 2016,10.1093...
Xie C, Yuan J, Li H, Li M, Zhao G, Bu D, Zhu W, Wu W, Chen R‡,Zhao Y‡. NONCODEv4: exploring the world of long non-coding RNA genes. Nucleic Acids Research 2014 Jan;42(Impact Factor:11.56SCI citation:227)
In fact, the portion of the genome responsible for protein coding constitutes approximately 1.5%, while many noncoding regulatory elements are transcribed into noncoding RNA (ncRNA), the implication being that ncRNAs could play significant regulatory roles in complex organisms. Indeed, the recent ...
参考文献:Ritu Chaudhary,Berkley Gryder,Wendy S Woods,et al. Prosurvival long noncoding RNA PINCR regulates a subset of p53 targets in human colorectal cancer cells by binding to Matrin 3[J]. eLife,2017,6:e23244
我公司在实验体系中设置阴性和阳性对照。 参考文献:Haiyan Guo, Jun Liu, Qiwen Ben,et al. The aspirin-induced long non-coding RNA OLA1P2 blocks phosphorylated STAT3 homodimer formation[J]. Genome Biology,2014, 10.1186
The evolutionary history of the medicinally important bulbous geophyte Drimia (subfamily: Scilloideae) has long been considered as a matter of debate in the monocot systematics. In India the genus is represented by a species complex, however, the taxonom