Some of the causal mutations are located in non-protein-coding regions of genes. When pathologically expanded, these repeats can trigger focal epigenetic changes that repress the expression of the mutant allele. When the mutant gene is not repressed, the transcripts containing the expanded repeat ...
Long intergenic non-coding RNAs (lincRNAs) have been implicated in both gene silencing and activation, and could be a means for long-range control of gene expression. Here a lincRNA termed HOTTIP is identified at the 5′ tip of the HOXA locus that coordinates the activation of multiple 5′...
The years following publication of the draft human genome sequence brought about a dramatic change in our understanding of the organization and expression of genetic information. Discoveries of new classes of RNA without protein coding potential and large scale cDNA sequencing projects demonstrated that, ...
Studies the association between divergence and interspersed repeats in mammalian noncoding genomic DNA. Variation in density of interspersed repeats and amount of noncoding sequence alignment; Local correlations between level of conservation and density of repeats; Variations in the rate of fixation of ...
Article Open access 15 December 2022 Host mitochondrial transcriptome response to SARS-CoV-2 in multiple cell models and clinical samples Article Open access 08 January 2021 Long non-coding RNA FENDRR regulates IFNγ-induced M1 phenotype in macrophages Article Open access 13 August 2020 Introduc...
Innovations in high-throughout sequencing approaches are being marshaled to both reveal the composition of the abundant and heterogeneous noncoding RNAs th
The discovery of the role of non-coding RNAs (ncRNAs) in the onset and progression of malignancies is a promising frontier of cancer genetics. It is clear that ncRNAs are candidates for therapeutic intervention, since they may act as biomarkers or key re
Circular RNAs (circRNAs), a novel type of non-coding RNAs (ncRNAs), are ubiquitously expressed in eukaryotic cells during post-transcriptional processes. Unlike linear RNAs, circRNAs form covalent-closed continuous loops without 5' to 3' polarities and poly (A) tails. With advances in high-...
With the development of sequencing technology, a large number of long non-coding RNAs (lncRNAs) have been identified in addition to coding genes. LncRNAs, originally considered as junk RNA, are dysregulated in various types of cancer. Although protein-co
long non-coding RNAs; cancer; tumor resistance; immunotherapy; immunosurveillance1. Introduction Cancer remains the second leading cause of mortality worldwide after cardiovascular diseases [1]. Cancer as a genetic disorder has its molecular base in the accumulation of multiple mutations, mostly in ...