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Biased and unbiased platelet phospho-proteomic profiling examined the OR2L13 signaling pathway. Results: 169 molecular hits were identified exceeding the 25% threshold, of which 6 ligands (CCF0054500, CCF0054432, CCF0053070, CCF0052249, CCF0051970 and CCF0058399) were persistently specific for OR2L...
Furthermore, systematic studies have shown that GWAS and eQTL methods are biased to identify different types of variants, with eQTLs being depleted at functionally important variants [79]. Therefore, the use of functional methodologies, such as crisprQTL, provides a complementary approach for gene ...
The optimality of Bartlett scores in the least squares sense in the class of conditionally unbiased factor scores is well known. The following lemma shows that the class of conditionally unbiased factor scores is the same class as factor scores with uncorrelated measurement errors, and both are ...
Guidelines for orthogonal CRISPR modalities (for example, CRISPRa) may differ from CRISPRi (as they differ at promoters48) and may be biased by library designs, phenotypic readouts, specific genomic loci perturbed and analysis methods used in these experiments. Building a larger, more diverse ...
Thus, the dual-CRISPR system was capable of interrogating both previously annotated and unannotated genomic regions in an unbiased fashion. Fig. 1: Identification of essential UCEs. a, MAGeCK algorithm was used to identify significant hits depleted from the cells cultured for an additional 15 ...
Since many of the prior studies (Zhang and Liu, 2015; Faisal et al., 2020; Usman et al., 2021) only rely on a single proxy for ICT, which may be accountable for biased estimation, this paper develops an ICT index comprising all three different proxies for ICT for robust findings. ...
For instance, analytical mistakes and biased HDL-C measurements can affect the estimation of non-HDL-C. Moreover, the current treatment threshold of non-HDL-C - set at 30 mg/dL higher than the LDL-C target-is debated and requires adjustment. Non-HDL-C reported at very high baseline TG ...
To ensure that the computed accuracies were not biased by subsampling of neurons, each session was decoded ten times using a randomly selected set of neurons, and we computed the average accuracy for each session. To determine the optimal value of k, the number of neighbors, we performed ...
Therefore, the results for the inclusive cohort can be expected not to be significantly biased. Comparison of Normal Status With Pre–Respiratory Sarcopenia and Respiratory Sarcopenia The PEFR cutoffs for men and women were 7.5 and 4.5 L/s, respectively. Accordingly, the PMI cutoffs for men ...