Pharmacology Non-alcoholic fatty liver disease alters the three stages of hepatic drug management THE UNIVERSITY OF ARIZONA Nathan J. Cherrington FisherCraig DIn pharmacotherapeutics, the term "correct dosing" is based on the concept that too high a systemic concentration will lead to drug toxicity...
There are two types of non-alcoholic fatty liver disease: Non-alcoholic fatty liver (NAFL) and non-alcoholic steatohepatitis (NASH). 1.Alcoholic在上文中是"酒精"的形容词形式,但也可以作为名词来使用,指"酗酒的人"。 2.Steatohepatitis意为"脂肪肝...
Onset can also occur after the use of drugs including amiodarone, antivirals, aspirin, corticosteroids, methotrexate, nifedipine, perhexiline, tamoxifen, tetracycline and valproic acid. However, the exact reason why stage 3 non-alcoholic fatty liver disease develops from more minor stages is unknown...
(Supplementary Table4). The p.His48Arg inADH1Bwas associated with reduced risk of alcohol dependence (P = 2.6 × 10−64, OR = 0.31,ncases = 60,800). We compared variant associations with alcoholic liver disease (ALD) diagnoses and NAFL diagnoses (Supplementary Fig.4)...
Liver metastasis is the major reason for most of colorectal cancer (CRC) related deaths. Accumulating evidence indicates that CRC patients with non-alcoholic fatty liver disease (NAFLD) are at a greater risk of developing liver metastasis. With the growi
Bedossa,Pierre - 《Liver International》 被引量: 151发表: 2017年 Liver breath tests non-invasively predict higher stages of non-alcoholic steatohepatitis H. (2003) The natural history of nonalcoholic fatty liver disease: a clinical histopathological study. Am. J. Gastroenterol. 98, 2042–2047 34...
aNon-alcoholic fatty liver disease (NAFLD) is characterized by an excessive accumulation of fatty acids and triglycerides within the cytoplasm of the hepatocytes of non-alcohol users. The natural history varies according to the initial histological diagnosis. A current consideration is that cryptogenic ...
OBJECTIVE—To determine the association between nonalcoholic fatty liver disease and the risk for development of diabetes.RESEARCH DESIGN AND METHODS—We conducted an observational cohort study in male workers ≥40 years old in a Japanese company from 1997 to 2005. We excluded workers with alcohol ...
Non-alcoholic fatty liver disease (NAFLD) has emerged pandemically across the globe and particularly affects patients with obesity and type 2 diabetes. NAFLD is a complex systemic disease that is characterised by hepatic lipid accumulation, lipotoxicity, insulin resistance, gut dysbiosis and inflammation...
Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver condition that affects a quarter of the global adult population. To date, only a few NAFLD risk prediction models have been developed for Chinese older adults aged ≥ 60 years. This study presented the development of a ...