Non-alcoholic fatty liver disease (NAFLD) is a chronic liver disease closely associated with features of the metabolic syndrome. NAFLD represents the most common aetiology of liver disease globally and encompasses a histopathological spectrum of disease ranging from simple steatosis to inflammation with ...
Non-alcoholic fatty liver disease (NAFLD) is a common, progressive liver disease strongly associated with the metabolic syndrome. It is unclear how progression of NAFLD towards cirrhosis translates into systematic changes in circulating proteins. Here, we provide a detailed proteo-transcriptomic map of...
LiverBurtLiverChristopherLiverPLiverDayLiverMcPherson S, Stewart SF, Henderson E, Burt AD, Day CP. Simple non-invasive fibrosis scoring systems can reliably exclude advanced fibrosis in patients with non-alcoholic fatty liver disease. Gut 2010;59:1265-9....
nutrients Article Nonalcoholic Fatty Liver Disease Is Exacerbated in High-Fat Diet-Fed Gnotobiotic Mice by Colonization with the Gut Microbiota from Patients with Nonalcoholic Steatohepatitis Chien-Chao Chiu 1, Yung-Hao Ching 2, Yen-Peng Li 3, Ju-Yun Liu 4, Yen-Te Huang...
ALT, alanine aminotransaminase; ARFI, acoustic radiation force impulse; AST, aspartate aminotransferase; BMI, body mass index; GGT, gamma-glutamyltransferase; HOMA, homeostatic model assessment; NAFLD, non-alcoholic fatty liver disease; TE, transient elastography. † n = 10. ‡ n = 3. ± n...
Sex hormone-binding globulin (SHBG), a glycoprotein synthesized by hepatocytes, has been linked to insulin resistance and hepatic lipid metabolism and is suggested to be associated with nonalcoholic fatty liver disease (NAFLD). This study aimed to invest
Abbreviations: BMI, body mass index; FDS, flavodiet score; KJ, kilojoule; NAFLD, nonalcoholic fatty liver disease; Q1–Q4, quantile; SD, standard deviation; T2DM, type 2 diabetes mellitus. Incident NAFLD Over a mean follow-up period of 10 y, 1081 cases of NAFLD were identified. The FDS...
The diagnosis and management of nonalcoholic fatty liver disease: practice guidance from the American Association for the Study of Liver Diseases. Hepatology. 2018;67(1):328-357. doi:10.1002/hep.29367PubMedGoogle ScholarCrossref 11. European Association for the Study of the Liver (EASL); ...
the complexity and incomplete understanding of the crosstalk between liver and adipose tissue, espe- cially the processes of hepatic lipogenesis and adipogenic differentiation, there are currently no effective drugs for the treatment of nonalcoholic fatty liver disease (...
The stage (or extent) of liver fibrosis, confirmed by biopsy, is believed to be a prognostic factor for risk death in people with non-alcoholic fatty liver disease (NAFLD). New Findings This systematic review and meta-analysis of 4428 patients in 13 studies found that, with and without adju...