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Ethynodiol diacetate是第一批合成的避孕药用孕激素之一。去甲二氢愈创木酸(NDGA) (< 1.5 μM)在150 μg/mL ethynodiol diacetate处理的人淋巴细胞中可以降低姐妹染色单体的交换率(SCEs)。在S9混合物存在的情况下NDGA处理会减轻ethynodiol diacetate 引起的遗传毒性损伤,这可能是通过对细胞色素P450s的抑制实现的...
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