Acknowledgements This work was supported by intramural funds provided by the University of Erlangen within an Emerging Field Initiative (Medicinal Redox Inorganic Chemistry). Additional support came from DFG (KFO130: LU728/3-1) to P.R. and from DFG (NA 970/1-1) to B.N. E.D.H. and P...
T2−heanodve1r5la0y μoMf thofe NspOec3−tr(aFfiogr. e6aCc)h, and of plasma-activated of the two conditions, at the same dilution factor (Fig. 6E), suggests that the mixture of these three species at the measured concentrations can adequately reproduce the chemistry ...
Why has such a small molecule received so much attention? Primarily because of the extraordinary biological effects and medically relevant processes mediated by NO. NO is at the heart of a number of complex regulatory mechanisms in the brain, immune, and cardiovascular systems. In the brain and ...
NOX1 and NOX4 in the hippocampi of stressed animals. In addition, the antioxidant/cytoprotective Nrf2/HO-1 cascade was dampened, as evidenced by the lowered hippocampal protein expression of Nrf2 and HO-1 signals. Interestingly, meloxicam administration mitigated depression manifestations and brain hist...
Series of studies reported an increase in oxidative stress additional to the persistent redox imbalance associated with HIV-1 infection manifested by an increase in oxidants and a decrease in antioxidant serum levels [49,50]. It is generally acknowledged that the components of ART may contribute to...
Of note, it has been also speculated that Trypanosoma brucei preferentially localizes in the brain areas expressing Ngb, a hemeprotein involved in the NO/O2 metabolism [182,206]. 5.2. Toxoplasma gondii The preferential localization in retina, heart, and skeletal muscle cells of T. gondii may ...