PDF Full Text Copy link Share via WhatsApp Share via mail Abstract Solid-state nuclear magnetic resonance (NMR) spectroscopy is an atomic-level method to determine the chemical structure, 3D structure and dynamics of solids and semi-solids. This Primer summarizes the basic principles of NMR ...
NMR SPECTROSCOPY / Principles 211 Rae AIM (1992) Quantum Mechanics, 3rd edn. Bristol: Institute of Physics. Vanhamme L, van den Boogaart A, and Van Huffel S (1997) Improved method for accurate and efficient quantification of MRS data with use of prior-knowledge. Journal of Magnetic Resonance...
NMR Spectroscopy. 1976 - 1995 Professional Services and Responsibilities: • Structure elucidation and spectral assignment by NMR spectroscopy in support of a wide range of pharmaceutical research and IND and NDA submissions. • Maintenance of Varian NMR instrumentation, including troubleshooting, meeting...
A rapid method for the isolation and identification of drug metabolites from human urine using solid phase extraction and proton NMR spectroscopy. J. Pharm. Biomed. Anal. 4, 663–665 (1986). CrossRef M. Tugnait, F.Y.K. Ghauri, I.D. Wilson and J.K. Nicholson. NMR monitored solid-...
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NMR spectroscopy has played a pivotal role in fragment-based drug discovery by coupling detection of weak ligand-target binding with structural mapping of the binding site. Fragment-based screening by NMR has been successfully applied to many soluble protein targets, but only to a limited number of...
Nuclear magnetic resonance (NMR) spectroscopy in solution is one of the key approaches for expanding this platform with dynamic features, which can be accessed at physiological temperature and with minimal modification of the wild-type GPCR covalent structures. Here, we review strategies for the use...
M., Gajan, D. & Emsley, L. Polymorphs of theophylline characterized by DNP enhanced solid-state NMR. Mol. Pharm. 12, 4146–4153 (2015). Article CAS PubMed PubMed Central Google Scholar Lesage, A. et al. Surface enhanced NMR spectroscopy by dynamic nuclear polarization. J. Am. Chem....
NMR spectroscopy for metabo‑ lomics and metabolic profiling. Anal Chem. 2015;87(1):133–46. 18. Wu J, Gao Y. Physiological conditions can be reflected in human urine proteome and metabolome. Expert Rev Proteomics. 2015;12(6):623–36. 19. An M, Gao Y. Urinary biomarkers of brain ...
6 which has been increasingly used to identify novel disease-specific signatures as potential biomarkers.7–9 Nuclear magnetic reso- nance (NMR) spectroscopy, liquid chromatography–mass spectro- scopy (LC–MS) and gas chromatography–mass spectroscopy (GC– MS) are the three major analytical ...