induce large magnetic field gradients that can significantly affect the NMR signals of nearby nuclei. These effects are known asParamagnetic Relaxation Enhancement (PRE)andPseudocontact Shifts (PCS). Studying these paramagnetic effects provides unique structural information, particularly over long distances, ...
Sections include a discussion on permanent magnets and their construction, magnetic field gradients, gradient amplifiers, RF amplifiers, probes and pre-amplifiers and NMR control systems including spectrometers, supervisor boards and host/control PCs. PFG NMR experiments have particularly demanding ...
The paramagnetic effect can be detected by an increased relaxation rate of nearby nuclei (PRE), pseudocontact shifts (PCS) and residual dipolar couplings (RDC) (Fig. 4). The PRE can be measured in any paramagnetic system, while PCS and RDC measurements require an anisotropic g-tensor, ...
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The PCs are composed of the scores and loadings. On one hand, the scores hold information about the samples (concentrations). Thus, PCA score plots of the first two or three PCs were used to visually observe the differences between the samples and immediately display sample clustering patterns ...
Hiromasa Yagi for helpful discussions on PCS and PRE measurements. This work was supported in part by funding from the National Health and Medical Research Council of Australia (Grants 1009785, 1099151) and the Australian Research Council (FT110100925). Authors contribution Project conception: MJS, ...
Taping Embossed 1500pcs Products characteristics table External Dimensions Dimension L Dimension W Dimension H Dimension e Dimension k (ref) 6.0 ±0.2 mm Inductance 2.2 uH ± 30 % 6.0x6.0 6.0 ±0.2 mm Max 4.5 mm 1.65 ±0.3 mm Min 0.3 mm ...
spectrum [26]. A principal component analysis method can identify and adjust individual peak variations through examining the correlation between peak-derivative shapes and the second or higher order principal components (PCs) [27]. As these two methods deal with every data points in the interested...
(D) Principal components (PCs) explaining more than 1% of the variation in NMR metabolite levels between samples (Methods). (E) Spearman correlation coefficients between the PCs and a selection of biological and environmental covariates. Heatmap cells are white and correlation coefficients are dulled...
PRE in drug discovery As shown in Eqs.1and3, the PRE for a given nuclear spin depends on the distance to the paramagnetic center (\(r^{ - 6}\)) but not the angle (Fig.1). As a result, the structural information provided has a shorter range and is not as rich as PCS data, wh...