Liposcale: a novel advanced lipoprotein test based on 2D diffusion-ordered 1H NMR spectroscopy. J Lipid Res. 2015. https://doi.org/10.1194/jlr.D050120. Article PubMed PubMed Central Google Scholar Fuertes-Martín R, Taverner D, Vallvé JC, Paredes S, Masana L, Correig Blanchar X, ...
addition, the quantification of the statistically significant metabolites identified in this TB metabolic profile would allow this technology to be adapted to a point-of-care test. Although more studies should be conducted in larger TB cohorts, vulnerable populations (children, HIV, comorbidities), and...
However, contrary to the two-class case where the OPLS-DA models always represent the class discrimination along the predictive component, in case of multi-classes the separation may not be along a single axis, thus turning interpretation less straightforward23. For this reason, also the two-...
In addition, the functions and mechanisms of the identified metabolite changes are also difficult to interpret; (3) The metabolome is very sensitive to many internal and external factors, so some minor differences may affect the metabolic profile of samples and cause challenges to data interpretation...
The amount and distribution of fat and lipid metabolites profile in the abdomen, liver, and calf muscles of 46 normal weight, 17 overweight, and 13 obese participants were acquired using MRI and MR spectroscopy (MRS), respectively. The serum metabolic profile was obtained using proton NMR spectro...
Then, the MetaboAnalyst (v4.0) software was used for metabolic pathway analysis and interpretation [236]. Eight pathways were statistically affected (FDR < 0.05) by the proposed profile of metabolites (see Table 3), thus five pathways stand out with high impact: the aminoacyl-tRNA biosynthesis;...