First, the validation of the results in a completely independent large cohort was not possible due to the lack of another cohort equally profiled. In addition, the number of individuals developing different kinds of cardiometabolic diseases in the follow-up was limited. To overcome this issue, ...
Lipophylic phenotype of thyroid lesions (both malignant and benign) was observed in the majority of NMR studies9,11,14,51. Our results are in agreement with these observations. Although further studies are required to understand the biochemical basis of the decreased lipid signals in the thyroid...
85.21% and 100% of the TB patients compared to pneumococcal pneumonia patients, LTBI and uninfected individuals, respectively. The model validation correctly classified 84.10% of the TB patients. We have identified and characterised a metabolic profile of TB in urine from a high-field NMR spectrome...
In addition, the functions and mechanisms of the identified metabolite changes are also difficult to interpret; (3) The metabolome is very sensitive to many internal and external factors, so some minor differences may affect the metabolic profile of samples and cause challenges to data interpretation...
(sugars and polyols, organic acids, and amino acids) and liposoluble metabolites (free and esterified fatty acids, sterols, and lipids) extracted from the maize grain was determined. Multivariate statistical analyses (PCA and ANOVA) pointed to the growing year and the variety as the most ...
(MRS), respectively. The serum metabolic profile was obtained using proton NMR spectroscopy. NMR spectra were integrated into seven integration regions, which reflect relative metabolites. Results: A significant metabolic disorder symptom appeared in the overweight and obese group, and increased lipid ...
Then, the MetaboAnalyst (v4.0) software was used for metabolic pathway analysis and interpretation [236]. Eight pathways were statistically affected (FDR < 0.05) by the proposed profile of metabolites (see Table 3), thus five pathways stand out with high impact: the aminoacyl-tRNA biosynthesis;...