据研究发现反复的癫痫发作可引起LTP诱导过程的紊乱和泛化,并且可以改变突触可塑性的阈值,进而引起认知损害。有趣的是,突触可塑性也可以反过来影响癫痫的发生和发展。而LTP的产生、维持与突触后膜上NMDA受体有密切关系。本文将深入探讨癫痫模型动物中LTP及NMDA受体的改变。 标签:癫痫;LTP;NMDA;认知 1973年,Bliss等[1]...
NMDAR-dependent LTP enhances neuronal differentiation and maturation of NPCs in the DG.Taesup ChoJae K. RyuChangiz TaghibiglouYuan GeAllen W. ChanLidong LiuJie LuJames G. McLarnonYu Tian Wang
? 2021 Elsevier LtdDrugs that block N-methyl-D-aspartate receptors (NMDARs) suppress hippocampus-dependent memory formation; they also block long-term potentiation (LTP), a cellular model of learning and memory. However, the fractional block that is required to achieve these effects is unknown. ...
An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in vitro. Neuropharmacology 46: 311-317, 2004.An NMDAR-independent LTP mediated by group II metabotropic glutamate receptors and p42/44 MAP kinase in the dentate gyrus in ...
Impaired hippocampal NMDAR-LTP in a transgenic model of NSUN2-deficiencyHarry George a bZafar I. Bashir aShobbir Hussain b
Barth AL, Malenka RC (2001) NMDAR EPSC kinetics do not regulate the critical 910 period for LTP at thalamocortical synapses. Nature Neuroscience 4:235-236.BARTH A L,MALENKA R C.NMDAR EPSCkinetics do not regulate the critical period for LTPat thalamocortical synapses. National Neuroscience . ...
Malenka RC (2001) NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses. Nat Neurosci 4:235–236 - ALBarth, A.L.; Malenka, R.C. NMDAR EPSC kinetics do not regulate the critical period for LTP at thalamocortical synapses. Nat. Neurosci., 2001, 4(3...
NMDAR activity during HFS is required for LTP-mediated changes in the spinogenesis of new neurons.Noriaki OhkawaYoshito SaitohEri TokunagaItsuko NihonmatsuFumiko OzawaAkiko MurayamaFumi ShibataToshio KitamuraKaoru Inokuchi
Different NMDAR subtypes mediate induction of LTP and two forms of STP at CA1 synapses in the rat hippocampus in vitro. J Physiol. 2013; 10 :955–972. doi: 10.1113/jphysiol.2012.247296. [ Cross Ref ]Volianskis A, Bannister N, Collett VJ, Irvine MW, Monaghan DT, Fitzjohn SM, Jensen...
AusteniteAccording to the solubility product theory of second phase in austenite, Ostward ripening theory, grain size control theory and precipitation strengthening theory, the probability for formation of inclusions in austenite and the inclusion size control have been theoretically analyzed and calculated...