Since metabolic disorders enhance NMDA receptor function, the redox site could constitute a new target for selectively preventing in vivo the deleterious consequences of overactivation without blocking neuronal plasticity mediated by NMDA receptors.
NMDA receptor (NMDAR) activation controls long-term potentiation (LTP) as well as long-term depression (LTD) of synaptic transmission, cellular models of learning and memory. A long-standing view proposes that a high level of Ca2+ entry through NMDARs triggers LTP; lower Ca2+ entry triggers...
relating nmda receptor function to receptor subunit composition: limitations of the pharmacological approach. the journal of neuroscience, 2006, 26(5): 13311333 11 feng b, tse h w, skifter d a, et al. structure-acti 60、vity analysis of a novel nr2c/nr2d-preferring nmda receptor antagonist...
Reports that both transient global forebrain ischemia in vivo and anoxia in vitro result in the specific expression of N-methyl-D-aspartate (NMDA) receptor 2B subunits in astrocytes and that their colocalization with NR1 subunits allows for the expression of functional NMDARs. Functional analysis ...
Autism-like social deficit generated by Dock4 deficiency is rescued by restoration of Rac1 activity and NMDA receptor function. Mol Psychiatry. 2021;26:1505–19. Article PubMed CAS Google Scholar Gao FB, Kohwi M, Brenman JE, Jan LY, Jan YN. Control of dendritic field formation in ...
This paper reviews the distribution, synthesis and physiological function of D-serine in nervous system. NMDA受体(N-methyl-D-aspartate receptor)是中枢神经系统内一类重要的兴奋性氨基酸(excitatory aminoacid, EAA)受体。NMDA受体不仅在神经系统发育过程中发挥着重要的生理作用,如可调节神经元的存活,调节神经元...
Increasing NMDA receptor hypofunction is associated with early occurring memory impairments followed by other schizophrenia-like symptoms. 展开 关键词: NMDA Ketamine Schizophrenia Memory Glutamate Cognition DOI: 10.1016/S0893-133X(98)00067-0 被引量: 1502 ...
(e.g., GluN1/2A/2B)1. NMDAR inhibition has been extensively studied to understand receptor structure and function, and to develop improved therapeutics. NMDAR channel blockers are inhibitors that block current by binding to the “deep site” at the outer tips of the pore-lining M2 reentrant...
Reduced NMDA receptor function is hypothesized to contribute to the pathophysiology of schizophrenia. In order to model chronic and developmental NMDA receptor hypofunction, a mouse line was developed that expresses low levels of the NMDA R1 subunit (NR1) of the NMDA receptor. The present study te...