The N-methyl-d-aspartate (NMDA) receptor has shown to play an important role in the cognitive deficits associated with developmental lead (Pb) exposure. In this study, we examined the effects of low-level Pb exposure on NMDA receptor subunit gene expression in the developing rat brain. The ...
a pharmacokinetically optimized GLP-1 receptor agonist approved for treatment of obesity and clinically available as a once-weekly injectable33. To directly evaluate the head-to-head weight-lowering potential of semaglutide versus GLP-1–MK-801, we performed single intracerebroventricular...
A form of receptor-mediated endocytosis, in which invagination of the endocytic vesicle is driven by the clathrin coat. Autaptic cultures Cultures in which hippocampal neurons are plated at an exceedingly sparse density so that each cell is physically isolated from other cells and makes synaptic conn...
Anti-N-methyl-D-aspartate-receptor (NMDAR) encephalitis and Myelin Oligodendrocyte Glycoprotein (MOG) associated disorders are both immune-mediated inflammatory disorders of the central nervous system [1,2]. Patients with NMDAR encephalitis usually present with a clinical syndrome including psychosis, beha...
NMDA Receptor Antagonistsare used as anesthetics for animals and sometimes humans, and are often used as recreational drugs because of theirhallucinogenicproperties. When NMDA Receptor Antagonists are given to rodents in large doses, they can cause a form of brain damage calledOlney's Lesions. Howev...
According to this idea, one could imagine that if one receptor is blocked and thus fails to induce a certain form of plasticity, the other type of receptor could take over its role, provided that conditions for inducing plasticity are generally favorable. In fact, this is what was observed ...
Similarly, NMDA receptor activity also increased them, an effect that antisense C/EBPβ blocked (Figures 5A and 5D; Supplemental Figures S4 and S5). Download: Download high-res image (1MB) Download: Download full-size image Figure 5. Nuclear C/EBPβ Levels Rapidly Rise in the Absence of ...
2002 . Regulated appearance of NMDA receptor subunits and channel functions during in vitro neuronal differentiation . JNeurobiol 51 : 54 – 65 .Jelitai, M.; Schlett, K.; Varju, P.; Eisel, U.; Madarasz, E. Regulated appearance of NMDA receptor subunits and channel functions during in ...
They form massive heterotetrameric complexes endowed with unique allosteric capacity provided by eight extracellular clamshell-like domains arranged as two superimposed layers. Despite an increasing number of full-length NMDAR structures, how these domains cooperate in an intact receptor to control its ...
NMDARs are heterotetramers typically composed of two GluN1 and two GluN2(A-D) and/or GluN3(A-B) subunits. NMDARs can assemble as diheteromers (e.g., GluN1/2A) or triheteromers (e.g., GluN1/2A/2B)1. NMDAR inhibition has been extensively studied to understand receptor structure and...