Nucleotide-binding domain and leucine-rich repeat (NLR) proteins are a prominent class of intracellular immune receptors in plants. However, our understanding of plant NLR structure and function is limited to the evolutionarily young flowering plant clade. Here, we describe an extended spectrum of NL...
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[本文引用: 1] [3]BernouxM,BurdettH,WilliamsSJ,ZhangXX,ChenCH,NewellK,LawrenceGJ,KobeB,EllisJG,AndersonPA,DoddsPN(2016). Comparative analysis of the flax immune receptors L6 and L7 suggests an equilibrium- based switch activation model Plant Cell28,146-159. URLPMID:26744216[本文引用: 1] [4...
近日,英国The Sainsbury Laboratory研究所Jonathan Jones研究组在PNAS发表了题为Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants的研究论文,该研究利用动植物NLR嵌合体激活植物免疫反应,揭示了植物TIR-NLR的作用机制。PNAS同时刊发了科罗拉多州立大学Bayless 和N...
Plant intracellular NLR immune receptors can function individually or in pairs to detect pathogen effectors and activate immune responses. NLR homeostasis has to be tightly regulated to ensure proper defense without triggering autoimmunity. However, in contrast to singleton NLRs, the mechanisms controlling...
Plants have developed a two-tiered immune system to detect and respond to potential threats in their environment6,7. The first line of defence, known as pattern-triggered immunity, is initiated when membrane-resident pattern recognition receptors recognize evolutionary conserved microbe-derived molecular...
Nucleotide binding and oligomerization domain (NOD)-like receptors (NLRB) mediate recognition of pathogen effectors inside the cell and trigger a host specific defense response, often involving controlled cell death. NLRB consist of a central nucleotide binding domain, which is flanked by an N-...
Nucleotide-binding leucine-rich repeat (NLR) receptors play crucial roles in plant immunity by sensing pathogen effectors1. In Arabidopsis, certain sensor NLRs function as NADases to catalyse the production of second messengers2,3, which can be recognized by enhanced disease susceptibility 1 (EDS...
The 3D crystal structures of three phytohormone receptors/receptor-partner that orientated in the same direction were displayed in the middle and the structures with 180º rotation were displayed in the right. f, Overlays of 3D structures of COI1, TIR1and MAX2 with the modeled structure of ...
Nucleotide-binding leucine-rich repeat (NLR) receptors play crucial roles in plant immunity by sensing pathogen effectors1. In Arabidopsis, certain sensor NLRs function as NADases to catalyse the production of second messengers2,3, which can be recognize