However, NLRs can also function in higher order pairs and networks of functionally specialized interconnected receptors. In this article, we cover the basic aspects of plant NLR biology with an emphasis on NLR networks. We highlight some of the recent advances in NLR structure, function, and ...
Most resistance proteins are intracellular nucleotide-binding leucine-rich repeat (NLR) receptors which play a crucial role in plant defence against pathogen invasion1,8. NLR receptors are multidomain proteins, which comprise a central nucleotide-binding domain (NBD) and a C-terminal leucine-rich rep...
紧接着的植物体内的ETI(effector-triggered immunity)作为第二个细胞内监测系统对于抵抗多种病原体侵染至关重要。研究表明,植物体内的ETI反应是由NLR受体(nucleotide-binding leucine-rich repeat receptors)介导。NLR蛋白通常由三个或多个结构域组成,其中NB-ARC(nucleotide-binding)结构域是NLR的核心组分并参与下游受体...
In plants, NLRs function at varying levels of connectivity, ranging from standalone “singleton” receptors sufficient to induce NLR-mediated immunity, paired NLRs that distribute perception (sensor) and transduction (helper) activities, and in fortified networks where a minimal set of helper NLRs fun...
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Abstract: A large area of membrane surface and intracellular immune receptors have been evolved in higher plants to sense various pathogen signals and prevent pathogen invasion. Among them, pattern recognition receptors on the cell surface activate basic immune response after sensing pattern molecules, ...
NLR receptors in plant immunity: making sense of the alphabet soup. EMBO Rep. 24, e57495 (2023). Article CAS PubMed PubMed Central Google Scholar Marchal, C., Haberer, G., Spannagl, M. & Uauy, C. Comparative genomics and functional studies of wheat BED-NLR loci. Genes (Basel) 11...
Plant intracellular NLR immune receptors can function individually or in pairs to detect pathogen effectors and activate immune responses. NLR homeostasis has to be tightly regulated to ensure proper defense without triggering autoimmunity. However, in c
Lou L, Tian M, Li Q, Ding Y, Cao X, Wu Y, Belda-Palazon B, Rodriguez PL, Yang S, Xie Q. (2016) ESCRT-I component VPS23A affects ABA signaling by recognizing ABA receptors for endosomal degradation. Mol Plant. 9:1570-1582.论文链接：https://doi.org/10.1093/plcell/koad061 想了...
Cell surface pattern recognition receptors (PRRs) are at the forefront of the plant immune system. PRRs recognise conserved pathogen-associated molecular patterns (PAMPs) in the plant extracellular apoplastic space, leading to PRR-mediated immunity (Figure 1) [1]. In turn, invading organisms have ...