作者发现,NKR-P1B敲除小鼠肠道中gdT细胞和ILC数目均显著上调,而肝脏、脾脏等组织不受影响。肠道驻留的ILC3,gdT细胞和NK细胞通过分泌相应的细胞因子抵抗病原微生物感染,为了探究NKR-P1B是否与肠道固有免疫细胞功能相关,作者进一步利用细菌感染...
In this study, we show that the inhibitory NKR-P1B receptor, but not the Ly49 receptor, is expressed in gut-resident NK cells, ILC, and a subset of γδT cells in a tissue-specific manner. ILC3 cells constitute the predominant cell subset expressing NKR-P1B in the gut lamina propria....
NKR-P1 receptor in rodents plays an important role in the potency of natural killer cells to kill tumour, or infected, or stressed cells. Several isoforms of NKR-P1 have been identified: NKR-P1A (activation receptor), and NKR-P1B, NKR-P1D (inhibitory receptors). Natural ligands for these ...
Using a newly developed congenic rat strain, LEW.NKC(BS), carrying the NKC of strain BS on the genetic background of strain LEW, we have now studied the genetic polymorphism of the NKR-P1B NK receptor and have generated a monoclonal antibody, HT31, detecting the NKR-P1B gene product of ...
Structures of NKR-P1B and Clr-b Both NKR-P1B and Clr-b adopted the classic CTLD fold comprising two central antiparallel β-sheets flanked by two α-helices (α1 and α2) (Fig.1). Each of the β-sheets was comprised of four β-strands, which we denote β0, β1, β5, β1′ ...
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NKR-P1B results in a higher frequency and number of ILC3 andγδT cells in the gut lamina propria.However,the function of gut-resident ILC3,NK,andγδT cells in NKR-P1B-deficient mice is impaired during gastrointestinal tract infection by Citrobacter rodentium or Salmonella typhimurium,resulting...
NKR-P1B results in a higher frequency and number of ILC3 andγδT cells in the gut lamina propria.However,the function of gut-resident ILC3,NK,andγδT cells in NKR-P1B-deficient mice is impaired during gastrointestinal tract infection by Citrobacter rodentium or Salmonella typhimurium,res...
NKR-P1B:Clr-b recognition is extremely sensitive to mutations at the heterodimeric interface, with most mutations severely impacting both Clr-b binding and NKR-P1B receptor function to implicate a low affinity interaction. Within the structure, two NKR-P1B:Clr-b complexes are cross-linked by a ...
A minor subset of NKp46(+) cells lacking expression of both Ly49 receptors and NKR-P1B is present in blood and spleen and is associated with decreased functional competence. We hypothesized that this subset may represent precursors to Ly49(+) and/or NKR-P1B(+) NK cells. When cultured in...