作者发现,NKR-P1B敲除小鼠肠道中gdT细胞和ILC数目均显著上调,而肝脏、脾脏等组织不受影响。肠道驻留的ILC3,gdT细胞和NK细胞通过分泌相应的细胞因子抵抗病原微生物感染,为了探究NKR-P1B是否与肠道固有免疫细胞功能相关,作者进一步利用细菌感染...
Using a newly developed congenic rat strain, LEW.NKC(BS), carrying the NKC of strain BS on the genetic background of strain LEW, we have now studied the genetic polymorphism of the NKR-P1B NK receptor and have generated a monoclonal antibody, HT31, detecting the NKR-P1B gene product of ...
NKR-P1B results in a higher frequency and number of ILC3 andγδT cells in the gut lamina propria.However,the function of gut-resident ILC3,NK,andγδT cells in NKR-P1B-deficient mice is impaired during gastrointestinal tract infection by Citrobacter rodentium or Salmonella typhimurium,resulting...
In this study, we show that the inhibitory NKR-P1B receptor, but not the Ly49 receptor, is expressed in gut-resident NK cells, ILC, and a subset of γδT cells in a tissue-specific manner. ILC3 cells constitute the predominant cell subset expressing NKR-P1B in the gut lamina propria....
However, self-ligand recognition remains poorly understood within the prototypical NKR-P1 receptor family. Here we report the structure of the inhibitory NKR-P1B receptor bound to its cognate host ligand, Clr-b. NKR-P1B and Clr-b interact via a head-to-head docking mode through an interface ...
相关信息:产品目录(40582) 用户评价 英文名称:Anti-NKR-P1B (CD161b), clone 2D12 欣博盛生物科技有限公司 联系电话:4006-800-892 电子邮件:info@neobioscience.com CB指数:58 网址:www.nbs-bio.com 相关信息:产品目录(6207) 用户评价 英文名称:Anti-NKR-P1B (CD161b), clone 2D12 Tag...
NKR-P1B results in a higher frequency and number of ILC3 andγδT cells in the gut lamina propria.However,the function of gut-resident ILC3,NK,andγδT cells in NKR-P1B-deficient mice is impaired during gastrointestinal tract infection by Citrobacter rodentium or Salmonella typhimurium,resul...
The goal of our research is to evaluate the role of NKR-P1B:Clr-b interaction in a solid tumour model, namely, breast cancer. We used a E0771 cell-induced mammary tumour model to evaluate mammary tumour growth, and the activity of tumour-infiltrating NK cells in NKR-P1B-deficient and WT...
Here, we elucidate the role of MHC-I-independent NKR-P1B:Clr-b interactions in the detection of oncogenic transformation by NK cells. Ras oncogene overexpression was found to promote a real-time loss of Clr-b on mouse fibroblasts and leukemia cells, mediated in part via the Raf/MEK/ERK ...
Kveberg L, Jimenez-Royo P, Naper C, Rolstad B, Butcher GW, Vaage JT, Inngjerdingen M (2010) Two complementary rat NK cell subsets, Ly49s3+ and NKR-P1B+, differ in phenotypic character- istics and responsiveness to cytokines. J Leukoc Biol 88:87-93...