The molecular details of ligand recognition and its connection to CD3ζ signaling remain unsolved. Here, we show that the stalk domain ( 129 KEHPQLGAGTVLLLR 143 ) of NKp30 is very sensitive to sequence alterati
against several tumor cell types and that it is the main receptor responsible for NK‑mediated lysis of immature dendritic cells (2, 5). The ligand(s) recognized by NKp30 has not been described. References Moretta, L. and A. Moretta (2004) EMBO J.23:255....
et al. The B7 family member B7–H6 is a tumor cell ligand for the activating natural killer cell receptor NKp30 in humans. J. Exp. Med. 206, 1495–1503 (2009). Article CAS Google Scholar Pandey, R., DeStephan, C.M., Madge, L.A., May, M.J. & Orange, J.S. NKp30 ...
The proto-oncogene Myc drives expression of the NK cell-activating NKp30 ligand B7-H6 in tumor cells. Oncoimmunology (2016) 5:e1116674. doi:10.1080/2162402X.2015.1116674The proto-oncogene Myc drives expression of the NK cell-activating NKp30ligand B7-H6in tumor cells. Textor S,Bossler F,...
Natural Cytotoxicity Triggering Receptor 3, NCR3, also known as NKp30, or CD337, is a natural cytotoxicity receptor, expressed on subsets of human peripheral blood NK cells, involved in NK cell killing of tumor cells and immature dendritic cells. The cellular ligand for NKp30 has remained elus...
CD70CD70/CD27 Ligand protein, recombinant TNFRSF13BTACI protein, recombinant MRC1MRC1/CD206 protein, recombinant V-set domain containing 官方名通用名 IGSF8IGSF8 protein, recombinant HAVCR1TIM-1/HAVCR1 protein, recombinant PIGRpIgR protein, recombinant ...
The cellular ligand for NKp30 has remained elusive, but the membrane-associated heparan sulfate (HS) proteoglycans are involved in the recognition of cellular targets by NKp30 was recently reported. NKp30 is a member of the immunoglobulin superfamily and one of three existing natural cytotoxicity-...
expressed high levels of the NKp30 ligand B7H6 (Fig.2f, g). Furthermore, to ascertain whether the NKp30-B7H6 interaction could also occur in vivo, we screened primary APL blasts for the expression of B7H6. Peripheral APL blasts expressed distinctly higher levels of B7H6 than their counterpa...
responsible for NK-mediated lysis of immature dendritic cells (2, 5). The B7 family member B7-H6, a tumor cell ligand, has been identified as activating NKp30 (6). Additionally, soluble galectin-3 released from tumor cells was found to bind NKp30 thereby inhibiting NKp30-mediated ...
Mimicking an induced self phenotype by coating lymphomas with the NKp30 ligand B7-H6 promotes NK cell cytotoxicity J Immunol, 189 (10) (2012), pp. 5037-5046 CrossrefView in ScopusGoogle Scholar 22 J Banchereau, RM Steinman Dendritic cells and the control of immunity Nature, 392 (6673) (...