Loop diuretics, targeting the transporter, are instrumental for relieving edema or hypertension. This review focuses on intrinsic mechanisms regulating NKCC2 activity at the posttranslational level, namely its trafficking and phosphorylation. Recent findings Protein networks mediating cellular turnover of NK...
NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell (1, 2). Transport of sodium dilutes the luminal fluid, decreasing its osmolality cr...
NKCC2, a kidney-specific member of the cation chloride co-transporter family SLC12, facilitates transport of sodium, potassium, and chloride ions from the lumen of the renal thick ascending limb into the cell (1, 2). Transport of sodium dilutes the luminal fluid, decreasing its osmolality cr...
A Rabbit Polyclonal Antibody to NKCC2 Transporter规格:25 µlCAS NO:0运输温度:Room temperature保存温度:-20厂家是否常备现货:Yes 产品留言 标题 联系人 联系电话 内容 验证码 点击换一张 注:1.可以使用快捷键Alt+S或Ctrl+Enter发送信息!2.如有必要,请您留下您的详细联系方式!
Michael–Menten's pattern for Na+ and K+ dependencies, binding of Cl− to NKCC is a cooperative process with a Hill coefficient of 2,52 providing high-efficiency regulation of carrier activity in the range of [Cl−]o existing in the JGA and close to the EC50 value of the transporter...
Renal cells of the thick ascending limb (TAL) reabsorb NaCl via the apical Na+/K+/2Cl− co-transporter NKCC2. Trafficking of NKCC2 to the apical surface regulates NKCC2-mediated NaCl absorption and blood pressure. The molecular mechanisms by which NKCC2 reaches the apical surface and ...
The role of the mitochondria may be particularly important for the reduction of NKCC2 and ENaCα , but not the other transporter. These findings not only shed new light on our understanding of the mechanisms underlying the obstruction-related dysregulation of renal sodium transporters, but also...
To determine how the major apical sodium transporter of the thick ascending limb (TAL), the bumetanide-sensitive Na-K-2Cl cotransporter (NKCC2) is regulated by high-fat feeding, we treated young male, Fisher 344 X Brown Norway (F344BN) rats for 8 weeks with diets containing either normal...
The thick ascending limb of Henle’s loop is a nephron segment that is vital to the formation of dilute and concentrated urine. This ability is accomplished by a consortium of functionally coupled proteins consisting of the apical Na+:K+:2Cl−co-transporter, the K+channel, and basolateral ...
NKCC2 belongs to the cation-chloride co-transporter (CCC)3 family, which comprises two principal branches of membrane proteins (1). One branch includes the Na+-dependent chloride co-transporters composed of the Na+-K+-2Cl− co-transporters (NKCC1 and NKCC2) and the Na+-Cl− co-tran...