根据细胞表面CD56的密度,将NK细胞分为 CD56bright和CD56dim 两者类型,它们具有不同的表型特征。CD56bright NK细胞具有产生丰富细胞因子的能力,而CD56dim NK细胞具有更强的细胞毒性,表达更多的免疫球蛋白样受体和FcγRIII (Fcγ受体III,又称CD16)。 激活性受体和抑制性受体均在NK细胞表面表达,有助于NK细胞执行功能。
采用流式细胞术检测脐血,母亲及对照组中NK细胞和CD56brightCD16dim/-NK细胞亚群的比率.结果脐血中淋巴细胞计数显著高于母亲及对照组;NK细胞比率无显著性差异;CD56brightCD16dim/-NK细胞高于母亲及对照组;母亲组CD56brightCD16dim/-NK细胞高于对照组.结论脐血中丰富的CD56brightCD16dim/-NK细胞是脐血低免疫应答的原因...
In humans, as previously mentioned, NK cells can be roughly divided into CD56brightCD16−and CD56dimCD16+NK cells (from here on referred to as CD56brightand CD56dimNK cells [3]. Although they are generally considered two distinct subsets, they seem to merely represent different stages of N...
Increased frequency of CD56 Bright NK-cells,CD3-CD16 + CD56-NK-cells and activated CD4 +T-cells or B-cells in parallel with CD4 + CD25 High T-cells control potentially viremia in blood donors with HCV[J].Journal of Medical Virology,2009,(01):49-59.doi:...
Lower CD56bright natural killer regulatory cells displayed differential impacts on the development of extensive chronic graft-versus-host disease between filgrastim-stimulated apheresis peripheral blood and filgrastim-stimulated bone marrow. In summary, while controlling for the potential impact of filgrastim ...
On the other hand, CD56(dim)CD16(bright) NK cells accumulate in the liver of patients with primary biliary disease aided by the CXCR1/CXCL8 axis. However, the types of chemokines that contribute to their accumulation in target ... AA Maghazachi - 《Curr Top Microbiol Immunol》 被引量: ...
CD56bright NKlow‐dose IL‐2NK cellsNKp44regulatory T cellsSummary Low‐dose interleukin (IL)‐2 has shown clinical benefits in patients with autoimmune and inflammatory diseases. Both regulatory T cells (Tregs) and natural killer (NK) cells are increased in response to low‐dose IL‐2 ...
Recent evidence has shown that CD56bright NK cells, a subset of NK cells abundant in lymph nodes, may have an immunoregulatory function. In multiple sclerosis (MS), expansion of CD56bright NK cells has been associated to successful response to different treatments and to remission of disease duri...
High number of CD56bright NK-cells and persistently low CD4+ T-cells in a hemophiliac HIV/HCV co-infected patient without opportunistic infections DOI: 10.1186/1743-422x-10-33 Fregni Giulia,Maresca Anaenza Freire,Jalbert Valérie,Caignard Anne Keywords: HIV , HCV , Opportunistic infections , ...