采用流式细胞术检测脐血,母亲及对照组中NK细胞和CD56brightCD16dim/-NK细胞亚群的比率.结果脐血中淋巴细胞计数显著高于母亲及对照组;NK细胞比率无显著性差异;CD56brightCD16dim/-NK细胞高于母亲及对照组;母亲组CD56brightCD16dim/-NK细胞高于对照组.结论脐血中丰富的CD56brightCD16dim/-NK细胞是脐血低免疫应答的原因之一.孙...
根据细胞表面CD56的密度,将NK细胞分为 CD56bright和CD56dim 两者类型,它们具有不同的表型特征。CD56bright NK细胞具有产生丰富细胞因子的能力,而CD56dim NK细胞具有更强的细胞毒性,表达更多的免疫球蛋白样受体和FcγRIII (Fcγ受体III,又称CD16)。 激活性受体和抑制性受体均在NK细胞表面表达,有助于NK细胞执行功能。
Journal of Neuroinflammation (2024) 21:48 https://doi.org/10.1186/s12974-024-03040-8 Journal of Neuroin ammation REVIEW The role of CD56bright NK cells in neurodegenerative disorders Open Access Carla Rodriguez‑Mogeda1,2,3†, Chaja M. J. van Ansenwoude1,2,3†,...
CD56bright NKlow‐dose IL‐2NK cellsNKp44regulatory T cellsSummary Low‐dose interleukin (IL)‐2 has shown clinical benefits in patients with autoimmune and inflammatory diseases. Both regulatory T cells (Tregs) and natural killer (NK) cells are increased in response to low‐dose IL‐2 ...
CD56dimcounterparts. Hence, this review focusses on NK cells, specifically on CD56brightNK cells, and their role in neurodegenerative diseases. Moreover, it explores the mechanisms underlying their ability to enter the central nervous system. By consolidating current knowledge, we aim to provide a ...
Zarife MA,,Reis EA,Carmo TM, et al.Increased frequency of CD56Bright NK-cells, CD3-CD16+CD56-NK-cells and activated CD4+T-cells or B-cells in parallel with CD4+CDC25High T-cells control potentially viremia in blood donors with HCV. Journal of Medical Vir...
CD56bright. An expansion in the CD56bright NK cell subset has been associated with clinical responses to therapy in various autoimmune diseases, suggesting an immunoregulatory role for this subset in vivo. Here we compared the regulation of activated human CD4+ T cells by CD56dim and CD56bright ...
NK cells are characterized by cytotoxic activity against tumor cells and CD3-CD16+CD56+ phenotype. Two distinct subpopulations of NK cells were characterized in the peripheral blood: NK-CD56dim representing over 95% of NK cells and involved in antitumor cytotoxicity, and NK-CD56bright representing ...
自然杀伤(nature kill,NK)细胞无需抗原预先致敏即可直接杀伤靶细胞,其发挥免疫效应早于T淋巴细胞,因此被视为机体免疫防御的第一道防线.但近年越来越多的研究表明CD56bright CD 16dim NK细胞亚型在肿瘤的生物学作用中扮演“帮凶”角色,现将近年关于CD5 6bright CD 16dim NK细胞在在肿瘤中发挥的效应综述如下....
Recent evidence has shown that CD56(bright) NK cells, a subset of NK cells abundant in lymph nodes, may have an immunoregulatory function. In multiple sclerosis (MS), expansion of CD56(bright) NK cells has been associated to successful response to different treatments and to remission of diseas...