1.静态NK细胞(Resting NK Cells) 静态NK细胞是体内处于休眠状态的NK细胞,通常在没有受到病原或肿瘤细胞兴奋的情况下,它们的免疫活性较低。当遇到细胞压力或病原侵袭时,静态NK细胞会被激活,快速进入工作状态。 2.活化NK细胞(Activated NK Cells) 活化NK细胞是在免疫兴奋后,尤其是肿瘤细胞或感染细胞的作用下,通过受体...
[5]Mercedes, B . F., Carolina, I . D., Norberto, W . Z. Leveraging NKG2D Ligands in Immuno-Oncology.Immunol., 29 July 2021 [6] Bryceson, Y . T.,March, M . E.,Ljunggren, H . G. & Long, E. O. Synergy among receptors on resting NK cells for the activation of natural cyto...
[4]S. J. Judge, et al, Minimal PD-1 expression in mouse and human NK cells under diverse conditions. J. Clin. Invest. 130, 3051–3068 (2020). [5]Z. Davis,et al, Low-density PD-1 expression on resting h...
[5]Mercedes, B . F., Carolina, I . D., Norberto, W . Z.Leveraging NKG2D Ligands in Immuno-Oncology.Immunol., 29 July 2021 [6] Bryceson, Y . T.,March, M . E.,Ljunggren, H . G. & Long, E. O. Synergy among receptors on resting...
[4]S. J. Judge, et al, Minimal PD-1 expression in mouse and human NK cells under diverse conditions. J. Clin. Invest. 130, 3051–3068 (2020). [5]Z. Davis,et al, Low-density PD-1 expression on resting human natural killer cells is functional and upregulated after transplantation. ...
Resting NK Celldoi:10.1007/978-3-642-16483-5_5061Are freshly isolated primary Natural Killer (NK) cells that have not been stimulated with cytokines in in vitro cultures. Natural Killer Cell ActivationSpringer Berlin Heidelberg
Target-cell lysis by IL-2-activated NK cells in a redirected, antibody-dependent cytotoxicity assay was triggered by a number of receptors. In contrast, cytotoxicity by resting NK cells was induced only by CD16, and not by NKp46, NKG2D, 2B4 (CD244), DNAM-1 (CD226), or CD2. Calcium...
Resting NK cells largely fail to kill hiPSC lines in contrast to K562 cells.Vanessa, KruseCarina, HamannSebastian, MoneckeLukas, CyganekLeslie, ElsnerDaniela, HübscherLutz, WalterKatrin, StreckfussBömekeKaomei, GuanRalf, Dressel
Human dendritic cells activate resting natural killer (NK) cells and are recognized via the NKp30 receptor by activated NK cells. J. Exp. Med. 195: 343– 351. Google Scholar Crossref PubMed WorldCat 4. Pende D., Castriconi R., Romagnani P., Spaggiari G. M., Marcenaro S....
Chimeric antigen receptors (CARs) are synthetic receptors that reprogram the target specificity and functions of CAR-expressing effector cells. The design of CAR constructs typically includes an extracellular antigen-binding moiety, hinge (H), transmembr