自然杀伤(NK)细胞可选择性地溶解细胞,而无需事先活化。NK细胞属于天然淋巴细胞(ILC),天然淋巴细胞作为天然免疫系统的一部分,对于免疫监视和随后的宿主防御病毒感染和癌细胞至关重要。在人体中,自然杀伤(NK)细胞占循环淋巴细胞的8-20%;在实验室的近交系小鼠中,NK细胞占脾脏...
The large cells on the left represent HuH7 cells. The small cells on the right represent NK cells. Scale bar, 0.5 μm. Data are representative of 9 samples. b, (related to Fig. 2c), TEM showing the interface of human liver-cancer cells and NK cells at low magnification. NK cells ...
Natural killer (NK) cells belong to the innate immune system and contribute to protecting the host through killing of infected, foreign, stressed or transformed cells. Additionally, via cellular cross-talk, NK cells orchestrate antitumor immune responses. Hence, significant efforts have been undertaken...
At low T cell concentrations, bsAb-activated T cells (mainly CD4 + T cells) were more effective than resting T cells at maintaining NK cell viability and ADCC. Brief (4h to 2day) bsAb exposure was sufficient to enhance long-term ADCC by NK cells. These findings raise the hypothesis that ...
Activation and expansion of A-NK cells are completed by day 14 of culture. At that point of A-NK cell culture, feeder cells are completely destroyed and used up, without any trace remaining. In addition, at that time, most of human A-NK cells are floating and they can be easily ...
Natural killer (NK) cell is a specialized immune effector cell type that plays a critical role in immune activation against abnormal cells. Different from events required for T cell activation, NK cell activation is governed by the interaction of NK rece
Molecular Cancer (2023) 22:34 https://doi.org/10.1186/s12943-023-01737-7 Molecular Cancer REVIEW NK cells are never alone: crosstalk and communication in tumour microenvironments Yongqiang Zhou1,2,3, Lu Cheng3, Lu Liu4 and Xun Li1,2,3* Open Access Abstract Immune...
Keywords:NKR;TLR;NKCells;innateimmunity;immuneregulation 0引言 免疫系统通过识别自我和非我保护机体免受外 来病原体的侵袭,同时又通过对自身抗原的免疫耐 受来防止自身免疫性疾病的发生.不适当的免疫应 答(对自身抗原产生应答、对外来致病原产生免疫耐 受或应答过强等)均会对机体造成严重损伤.为维持 机体内环境...
The persistence of undetectable disseminated tumour cells (DTCs) after primary tumour resection poses a major challenge to effective cancer treatment1–3. These enduring dormant DTCs are seeds of future metastases, and the mechanisms that switch them fro
The function of MR1-restricted mucosal-associated invariant T (MAIT) cells in tumor immunity is unclear. Here we show that MAIT cell-deficient mice have enhanced NK cell-dependent control of metastatic B16F10 tumor growth relative to control mice. Analys