Activation and expansion of A-NK cells are completed by day 14 of culture. At that point of A-NK cell culture, feeder cells are completely destroyed and used up, without any trace remaining. In addition, at that time, most of human A-NK cells are floating and they can be easily ...
自然杀伤(NK)细胞可选择性地溶解细胞,而无需事先活化。NK细胞属于天然淋巴细胞(ILC),天然淋巴细胞作为天然免疫系统的一部分,对于免疫监视和随后的宿主防御病毒感染和癌细胞至关重要。在人体中,自然杀伤(NK)细胞占循环淋巴细胞的8-20%;在实验室的近交系小鼠中,NK细胞占脾脏...
Natural killer (NK) and natural killer T (NKT) cells are two important cell subsets of the innate immune system. NK and NKT cells share many phenotypes and functions for anti-tumor immunity; however, the dynamic changes in phenotypes and functional inter
Finally, we review work that shows that NK cells develop at sites that were traditionally thought to be occupied only by adaptive immune cells, including the thymus and lymph nodes. 展开 关键词: natural killer cell innate immunity memory IL-22 cytokine ...
Natural killer (NK) cells, which are innate lymphocytes endowed with potent cytotoxic activity, have recently attracted attention as potential anticancer therapeutics. While NK cells mediate encouraging responses in patients with leukemia, the therapeuti
Innate lymphoid cells (ILC), including natural killer (NK) cells, are implicated in host-defense and tissue-growth. However, the composition and kinetics of NK cells in the intestine during the first year of life, when infants are first broadly exposed to exogenous antigens, are still unclear...
The numbers next to the gates represent the percentage of that population within total NK cells at the respective time point. Two populations with different kinetics of appearance are marked (the population on the top right is included in Figure 1C). (B–E) (B and C) Comparison of the ...
cells underscore the need to develop novel cell therapy products that are universal, safe, and potent. Natural killer (NK) cells are part of the innate immune system with unique advantages, including the potential for off-the-shelf therapy. A recent first-in-human trial of CD19-CAR-NK in...
(a–c) Quantitative reverse transcription-PCR (RT-PCR) analysis of the indicated genes in sorted CD3 À NK1.1 þ cells from the spleen of WT mice before and after stimulation with 25 ng ml À 1 IL-15 for 18 h (a), various concentration of IL-15 (b), or at the indicated ...
Maternal NK cells accumulate at the maternal-fetal interface and can interact with MHC class I molecules from both parents. The relative contribution of the two sets of parental MHC molecules to uterine NK cell function is unknown. Here we show that, in mice, maternal and not paternal MHC ...