[4]Montfoort N V , Borst L , Korrer M J , et al. NKG2A Blockade Potentiates CD8T Cell Immunity Induced by Cancer Vaccines - ScienceDirect[J]. Cell, 2018. [5]Mercedes, B . F., Carolina, I . D., Norberto, W . Z.Leveraging NKG2D L...
Given their potent antitumour activity, therapeutic manipulation of NK cells provides an attractive strategy for cancer treatment. A balance of inhibitory and stimulatory signals delivered by numerous receptors regulates NK cell functions (cytotoxicity, cytokine production and proliferation). NKG2D is the ...
NK细胞(naturalkiller cell),即自然杀伤细胞,是防御病毒感染和肿瘤侵袭的第一道防线,具有广谱消灭癌细胞的特性。科学家研究发现,在原发性肝癌组织中,NK细胞数量明显比其它正常组织中要低,且NK细胞的活性显著降低,而体外培养的 NK 细胞对肝癌细胞表现出明显的杀伤作用【2,3】。可以说,NK细胞免疫疗法在肝癌治疗中有...
et al. A gene signature predicting natural killer cell infiltration and improved survival in melanoma patients. Cancer Immunol. Res. 7, 1162–1174 (2019). Article CAS PubMed Google Scholar Barry, K. C. et al. A natural killer–dendritic cell axis defines checkpoint therapy–responsive tumor ...
5. Anna Bunin, Ann Marie Rossi, Christian Vidal, David Trihn, Marco Garcia, Joseph Woska, Lawrence Iben, Luca Rastelli, Paul Volden, Enrique Alvarez; Abstract 1478: Human transgenic IL-15 NOG mice reconstituted with human NK cells as a model for NK cell depletion. Cancer Res 1 July 2019...
Ghoneum, M.; Brown, J. NK Immunorestoration and cancer patients by BioBran/MGN-3, a modified aracbynoxylan rice bran (Study of 32 patients followed for up to 4 years). Ghoneum, M.; Abedi, S. Enhancement of natural killer cell activity of aged mice by modified arabinoxylan rice bran...
This Review discusses the role of natural killer (NK) cells in immunosurveillance of tumour cells, highlighting the new therapeutic approaches to NK cell targeting in the treatment of cancer and improvement of NK cell-mediated antitumour immune responses
通过Oncomine数据库(https://www. oncomine.org/resource/login.html)在线分析泛癌组织的基因芯片数据中RSPO3的表达[23],通过癌细胞系百科全书(Cancer Cell Line Encyclopedia,CCLE)数据库(https://sites. broadinstitute.org/ccle)在线分析泛...
[23]HARTWIG T, MONTINARO A, von KARSTEDT S, et al. The TRAIL-induced cancer secretome promotes a tumor-supportive immune microenvironment via CCR2[J]. Mol Cell, 2017, 65(4): 730-742. e5. [24]JI J, EGGERT T, BUDHU A, et al. Hepatic stellate cell and monocyte interaction contributes...
cancer. Current strategies in preclinical and clinical development include adoptive transfer therapies, direct stimulation, recruitment of NK cells into the tumor microenvironment (TME), blockade of inhibitory receptors that limit NK cell functions, and therapeutic modulation of the TME to enhance ...