The nitro-Mannich reaction belongs to a formidable suite of carbon-carbon bond-forming reactions, the aldol, Mannich, and Henry reactions that are all well understood and used routinely in molecular construction. They are all linked by the common addition of a stabilized anion to a carbonyl deriv...
M. K. 'The Nitro- Mannich Reaction and Its Application to the Stereoselective Synthesis of 1,2-Diamines" J. Org. Chem. 1998, 63, 9932. 'Adams H,Anderson J C,Peace S,et al.The Nitro-Mannich reaction and its application to the stereoselective synthesis of1,2-diamines. Journal of ...
Anderson JC, Koovits PJ. 2013. An enantioselective tandem reduction/nitro-mannich reaction of nitroalkenes using a simple thiourea organocatalyst. Chemical Science 4:2897-2901 DOI 10.1039/c3sc50613d.Anderson, J.C.; Koovits, P.J. An enantioselective tandem reduction/nitro-Mannich reaction of ...
Anderson JC, Koovits PJ. 2013. An enantioselective tandem reduction/nitro-mannich reaction of nitroalkenes using a simple thiourea organocatalyst. Chemical Science 4:2897-2901 DOI 10.1039/c3sc50613d.Anderson, J.C.; Koovits, P.J. An enantioselective tandem reduction/nitro-Mannich reaction of ...
Radical cyclisation studies of β-nitroamines from the nitro-Mannich reactionCyclisationFree radicalIndanesCyclopentanesNitro-MannichA range of novel 尾-nitroacetamides with an alkenyl- or alkynyl tether were synthesized using the deprotonative or conjugate addition nitro-Mannich reaction. They were ...
Yamada K I,Moll G,Shibasaki M.The first enantioselective and diastereoselective catalytic nitro-mnnich reaction: a new entry to chiral vicinal diamines. Synlett . 2001The First Enantioselective and DiastereoselectiveCatalytic Nitro-Mannich Reaction: A New Entry to Chiral Vicinal Diamines. Yamada K.-...
ChemInform Abstract: Highly Efficient Asymmetric Three‐Component Vinylogous Mannich Reaction Catalyzed by a Chiral Scandium(III)‐N,N′‐dioxide Complex. CheminformHighly efficient asymmetric three-component vinylogous Mannich reaction catalyzed by a chiral scandium (Ⅲ)-N,N’’-dioxide complex. Zhang, ...
Several control experiments were performed; the coupling reaction outcomes indicated that the CN coupled intermediate (N‐Mannich base) formed from the tertiary amine and NIS had a stabilizing effect on the iminium cation.Yusan, BulunuerAmuti, Adila...
(Chemical Equation Presented) A variety of 1,2-dihydroisoquinoline derivatives 3 have been prepared in good to high yields by the AgOTf-catalyzed reaction of ortho-alkynylaryl aldimines 1 with various pronucleophiles 2 (see scheme). Treatment of 1 with a stoichiometric amount of AgOTf followed...
The one pot conjugate addition nitro-Mannich reaction was unsuccessful except for the addition of alkoxides to 2 in alcohol as solvent. Isolation of the conjugate addition products followed by deprotonation with nBuLi and treatment with a simple imine in the presence of TFA led to 尾-nitroamine ...