A number of observations led to the following mechanism (Scheme 1).23 (5) Sign in to download full-size image Scheme 1. By using displacement reactions even nitriles that carry a number of functional groups may be prepared. Dinitriles may also be obtained by this method; in the case ...
Nitrile hydratases (NHases) have an unusual iron or cobalt catalytic center with two oxidized cysteine ligands, cysteine-sulfinic acid and cysteine-sulfenic acid, catalyzing the hydration of nitriles to amides. Recently, we found that the NHase of N771 exhibited an additional catalytic activity,...
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Nitrile binding to the cobalt active site is found to lower the energy of the nitrile π* orbital, thus activating the nitrile for nucleophilic attack. The presence of a strong ligandfield at the cobalt center is shown to be essential for this nitrile activation. Arguing against mechanism 2, ...
Carboxylic Acid to Acid Chloride6m Fischer Esterification5m Acid-Catalyzed Ester Hydrolysis4m Saponification3m Transesterification5m Lactones, Lactams and Cyclization Reactions10m Carboxylation5m Decarboxylation Mechanism14m Review of Nitriles46m 23. The Chemistry of Thioesters, Phophate Ester and ...
We conclude that the α-subunit is the minimal sequence needed for nitrile hydration providing a simplified scaffold to study the mechanism and post-translational modification of this important class of catalysts. 展开 DOI: 10.1021/bi500260j 被引量: 11 ...
Nitriles are produced by reacting together an organic nitrile with a carboxylic acid, said nitrile, said carboxylic acid and the carboxylic acid corresponding to said organic nitrile having a higher boiling point than the nitrile which it is desired to produce, at an elevated temperature and distil...
Fig. 4: Step-by-step hydrogenation mechanism of benzonitrile to benzylamine on Pd1/ND@G and Pdn/ND@G. Color code: Pd1/ND@G (green line) and Pdn/ND@G (blue line). Pd cyan, C gray, H white. Full size image On Pd3-Graphene (Pd3-Gr), H2molecule easily dissociates after the ad...
Deter- mination of organonitriles using enzyme-based selectivity mechanism. Anal Chem 1993; 65: 3134.Liu Z, Wang Y, Kounaves SP, Brush EJ (1993) Determination of organonitriles using enzyme-based selectivity mechanisms 1. an ammonia gas sensing electrode-based sensor for benzonitrile. Anal ...
The acid-base titration was used to determinate carboxyl content of the PSAs (Ai et al., 2017). Sample of 4.0 g was dissolved in 10 mL pyridine in N2 atmosphere, and thymolphthalein as indicator was added. Show abstract Investigating the effect of organoclay montmorillonite and rubber ratio...