Aging is accompanied by possible cognitive impairment, as well as a reduction in nitric oxide (NO) bioavailability, insulin resistance, and vitamin D deficiency. Among these Nitric oxide exhibits a dual role in brain biology, where both low and high leve
The nitric oxide-cyclic GMP signal transduction system for intracellular and intercellular communication. Recent Prog Horm Res. 1994;49:239–248. [50] Wiesner B, Weiner J, Middendorff R, Hagen V, Kaupp UB, Weyand I. Cyclic nucleotide- gated channels on the flagellum control Ca2+ entry into ...
Novel pharmacological and nutritional strategies that increase nitric oxide bioactivity and reduce oxidative stress could be potential therapies for preventing and treating kidney disease and associated cardiometabolic complications.This is a preview of subscription content, access via your institution Access opt...
1.1Nitric oxide Nitric oxide(NO) is one of the smallest known, endogenously derived signaling molecules, with a vast range of effects observed within the body. Regulation of NO within the body is pertinent for maintaininghomeostasis, particularly metabolic andcardiovascular functionregardingvascular tone...
Nitric oxide (NO) is a diffusible free radical and universal messenger that is produced from L-arginine by three different isoforms of nitric oxide synthases (NOS), neuronal (nNOS), inducible (iNOS) and endothelial NOS (eNOS). NO plays an important role
Among many other molecules, nitric oxide insures the correct progress of sperm capacitation by mediating phosphorylation events. For a more comprehensive understanding of how this happens, we capacitated human spermatozoa from healthy men in the presence/absence of S-Nitrosoglutathione, a nitric oxide ...
Dendritic-cell (DC) migration to secondary lymphoid organs is crucial for the initiation of adaptive immune responses. Although LPS up-regulates CCR7 on DCs, a second signal is required to enable them to migrate toward the chemokine CCL19 (MIP-3β). We found that the nitric oxide (NO) ...
Nitric oxide (NO) may contribute to the persistence of high-risk human papillomavirus (hrHPV) infection, which has been linked to the development of premalignant lesions and cervical cancer. Our study aimed to examine the relationship between cervical NO metabolite (NOx) levels, hrHPV infection, ...
Epidemiological studies have proven that exposure to Arsenic (AS) leads to the development of many neurological disorders. However, few studies have investigated its molecular mechanisms in the brain. Our previous work has revealed nitric oxide (NO)-medi
NOS3, gene encoding for nitric oxide synthase 3, is located on chromosome 7q355 and has been widely studied in several AD populations. Dahiyat et al.6 first found a significant effect of the G allele and the GG genotype of NOS3 G894T polymorphism on AD development. Subsequently, this ...