Importantly, at a dose of 200 mg/kg (BID) of nirmatrelvir, the compound was still able to reduce the lung infectious virus titers of 3CLprores-infected hamsters by 1.4 log10 with a modest improvement in the lung histopathology as compared to the vehicle control. Fortunately, resistance ...
3 Peking Uni- versity Clinical Research Institute, Peking University First Hospital, No. 8 Xishiku Street, Xicheng District, Beijing 100034, China. 4 Key Laboratory of Epidemiol- ogy of Major Diseases (Peking University), Ministry of Education, Beijing, China. 5 Pulmonary and ...
Department of Pathology and Cell Biology, Columbia University Vagelos College of Physicians and Surgeons, New York, NY, USA Seo Jung Hong & Alejandro Chavez Integrated Program in Cellular, Molecular, and Biomedical Studies, Columbia University Vagelos College of Physicians and Surgeons, New York, NY...
https://ror.org/00cvxb145grid.34477.330000 0001 2298 6657Department of Laboratory Medicine & PathologyUniversity of Washington Seattle WA USAJudith M. Whitehttps://ror.org/0153tk833grid.27755.320000 0000 9136 933XDepartment of Cell BiologyUniversity of Virginia Charlottesville VA USAJoshua T. Schiffer...
Capital Medical University granted an exemption from requiring informed consent. However, for patients who were followed up during the course of the study, verbal informed consent was obtained. This procedure was approved by the ethics committee and is in compliance with the Declaration of Helsinki....
All experiments using infectious SARS-CoV-2 strains were approved by the Georgia State Institutional Biosafety Committee under protocol B20016 and performed in BSL-3/ABSL-3 facilities at the Georgia State University. Study design Male and female Roborovski dwarf hamsters (Phodopus roborovskii, 3–4...
The component of the trial reported here was conducted in the Hospital for Tropical Diseases, Faculty of Tropical Medicine , Mahidol University, Bangkok, Thailand. We recruited low-risk adult patients aged 18–50 years with early symptomatic COVID-19 (<4 days of symptoms). Eligible patients ...
(ATCC VR-740) were gifted from Wuhan University. The SARS-CoV-2 strains, HCoV-OC43, and HCoV-229E were propagated in Vero E6, RD, and MRC5 cells, respectively. All experiments with authentic SARS-CoV-2 viruses were carried out in the Biosafety Level 3 facility (BSL-3) of the Wuhan...
These data confirm reports of similar efficacy in older adults and inform on possible epidemiologic benefit of antiviral treatment.doi:10.1038/s41467-023-40556-8Robert M. Coxhttps://ror.org/03qt6ba18grid.256304.60000 0004 1936 7400Center for Translational Antiviral ResearchGeorgia State University ...
The antiviral studies were performed in the Guangzhou Customs District Technology Center Biosafety Level 3 (BSL-3) Laboratory and approved by the Guangzhou Medical University Ethics Committee of Animal Experiments (Institutional Animal Care and Use Committee (IACUC) certificate number GZL0008). The pharm...