NEAR INFRARED (NIR) PHOTODYNAMIC THERAPY (PDT) IN COMBINATION WITH CHEMOTHERAPYMethods for treatment of cancer are provided. The methods are based on the use of both NIR photosensitizer(s) and chemotherapy agent(s). The NIR photosensitizers have a tetrapyrrolic core or reduced tetrapyrrolic core....
光动力学治疗(photodynamic therapy,PDT)是将光吸收剂与非电离光的物理能相结合进而杀死细胞。但是,它在肿瘤治疗中并不常用,原因是非靶向的光吸收剂也能够被正常组织摄取,经光照后即可引发严重的副作用[1]。为此,寻求光吸收剂肿瘤靶向传递的新策略是当前研究的热点。 近红外光免疫治疗(near infrared photoimmunotherapy...
光热疗法(photothermal therapy,PTT)是利用光热剂(photothermal agent,PTA),在近红外光(near-infrared,NIR)照射下,将光能转变为热能杀伤肿瘤细胞的一种无创性肿瘤治疗新方法,具有不良反应小、特异性高等优点[3],然而,PTT对正常组织的热损伤一直是难以解决的问题,如何平衡杀伤效率和正常组织保护能力一直困扰着研究人员。...
摘要 由于具备组织穿透深度深和时空分辨率高等优势, 近年来近红外二区(Near-infrared-Ⅱ, NIR-Ⅱ, 1000~1700 nm)荧光成像技术得到了快速发展, 其在肿瘤临床诊断和治疗的潜力更是引发了广泛关注. 本文首先阐释了NIR-Ⅱ窗口荧光成像的原理及其优势, 随后根据结构分类归纳总结了现有荧光团的特征, 重点介绍了荧光探针在...
相关工作以“Thermal-Responsive MXene-DNA Hydrogel for NearInfrared Light Triggered Localized Photothermal-Chemo Synergistic Cancer Therapy”为题目,于2022年09月03日发表在《Small》上。 方案1 负载 DOX 的 MXene-DNA 水凝胶的构建及其用于NIR触发局部光热-化疗协同癌症治疗的机理 1. MX-DNA水凝胶的制备及表征...
In contrast, near-infrared (NIR) light (650–1450 nm) penetrates deep into the tissues because biological systems are almost transparent to light within this so-called ‘imaging window’. Here we used lanthanide nanoparticles (LNPs), composed of rare-earth elements, as luminous bodies to ...
最近的研究表明,近红外(Near-infrared, NIR)光照诱导的光热效应可提高BBB的通透性,这为治疗PD提供了可靠的手段。相对于NIR-I区(700-1000 nm),NIR-II区(1000-1700 nm)更适合在生物体内环境中使用,它与减少光子散射、更深的组织渗透性和更大的最大允许暴露量有关。这种NIR-II照射可穿透头皮和颅骨下2.4 mm,更...
Near infrared (NIR) fluorescence-active fluorophores with excell... X Wu,X Sun,Z Guo,... - 《Journal of the American Chemical Society》 被引量: 145发表: 2014年 An Activatable Theranostic for Targeted Cancer Therapy and Imaging A new theranostic strategy is described. It is based on the ...
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Near-infrared intravascular ultrasound coronary imaging (e.g., the InfraReDx LipiScan™ IVUS Imaging System) for all indications (e.g., for detecting lipid-rich plaques and guiding cholesterol-lowering therapy); Near-infrared spectroscopy (NIRS) using spatial frequency domain imaging (SFDI) techno...