2024年8月19日,东华大学李静超团队在Advanced Science在线发表题为“Neutrophil-Targeting Semiconducting Polymer Nanotheranostics for NIR-II Fluorescence Imaging-Guided Photothermal-NO-Immunotherapy of Orthotopic Glioblastoma”的研究论文。该研究报道了中性粒细胞靶向半导体聚合物纳米治疗剂(SSPNiNO)用于小鼠模型中原位胶质...
IRFEM 旨在实现荧光、热量和 ROS 生成能力的平衡，因此使其成为 NIR-II 成像引导的 PTT/PDT 联合治疗的理想候选者。制备的IRFEM@DHP可以通过增强渗透性和保留率（EPR）效应在鼻咽癌细胞中富集，然后倾向于在酸性溶酶体中积累以释放IRFEM。之后，IRFEM可以通过大量的吗啉特异性靶向溶酶体，并在光照射下产生大量的热...
Lysosome-Targeted and pH-Activatable Phototheranostics for NIR-II Fluorescence Imaging-Guided Nasopharyngeal Carcinoma Phototherapy[J]. Bioconjugate Chemistry, 2024. ⭐️ ⭐️ ⭐️ 动物活体荧光成像系统 - MARS In Vivo Imaging System 高灵敏度 - 采用深制冷相机,活体穿透深度高于15mm 高分辨率 - ...
Y. Yang, C. Cen, L. Kan, Q. Zhao, Z. Huang, S. Li. Organic probes for three-photon fluorescence imaging in NIR-II window: Design, applications, and perspectives.Interdiscip. Mater.2025; 4(1): 109-137. doi: ...
Pu, T.; Liu, Y.; Pei, Y.; Peng, J.; Wang, Z.; Du, M.; Liu, Q.; Zhong, F.; Zhang, M.; Li, F.; Xu, C.; Zhang, X., NIR-II Fluorescence Imaging for the Detection and Resection of Cancerous Foci and Lymph Nodes in Early-Stage Orthotopic and Advanced-Stage Metastatic Ov...
目前，这是首次使用聚合物纳米诊疗平台，在NIR-II荧光成像引导的原位GBM PTT-NO-免疫治疗中的开创性研究。参考文献 Liu J, Cheng D, Zhu A, et al. Neutrophil゛rgeting Semiconducting Polymer Nanotheranostics for NIR㊣ Fluorescence Imaging﹗ided Photothermal㎡﹎munotherapy of Orthotopic Glioblastoma[J]. ...
NIR-II fluorescence lifetime imaging system 本文利用NIR-II-LT完成了小鼠活体肝脏和胃的荧光寿命成像实验。NIR-II-LT是一款长荧光寿命(微秒-毫秒)成像的近红外二区系统,用于表征体内或体外探针的荧光寿命信息。搭载深度制冷的InGaAs近红外相机能够满足长时间曝光成像,尤其对于弱光能有很高的采集效率。自主开发的荧光...
参考文献Diao, S.; Shi, W.; Liu, Y.; Liang, T.; Xu, Z.; Zhou, W.; Xie, C.; Fan, Q., Iron-chelated semiconducting oligomer nanoparticles for NIR-II fluorescenceimaging-guided enhanced chemodynamic/photothermal combination therapy. Journal of Materials Chemistry B 2023, 11 (38), 9290-...
Thus, we utilize NIR-II fluorescence imaging to achieve precise PTT-induced pyroptosis activation in glioma. A polymer semiconductor-based PTT agent was developed with high optical stability, integrated with mesoporous silica to enhance its biocompatibility. These nanoparticles, stabilized through PEG ...
Keywords:Near-infrared-Ⅱ ; Fluorescence imaging ; In vivo imaging ; Drug delivery ; Tumor diagnosis and therapy 肿瘤因其高病死率和复发率, 已成为威胁人类健康的重大疾病之一. 由于发现不及时, 很多患者在接受治疗时癌细胞已经转移和扩散, 错过了最佳治疗时机[1,2]. 因此, 肿瘤的早期诊断对于及早干预, ...