Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a ...
Nipah virus (NiV) is a non-segmented, negative-strand (NNS) RNA virus, belonging to Paramyxoviridae. The RNA polymerase complex, composed of large (L) protein and tetrameric phosphoprotein (P), is responsible for genome transcription and replication by catalyzing NTP polymerization, mRNA capping a...
Host cell recognition by the henipaviruses: crystal structures of the Nipah G attachment glycoprotein and its complex with ephrin-B3. Proc. Natl Acad. Sci. USA 105, 9953–9958 (2008). Article CAS PubMed PubMed Central Google Scholar Negrete, O. A. et al. EphrinB2 is the entry ...
The Nipah virus (NiV), a member of the Paramyxoviridae family, is notorious for its high fatality rate in humans. The RNA polymerase machinery of NiV, comprising the large protein L and the phosphoprotein P, is essential for viral replication. This study presents the 2.9-Å cryo-electron mi...
Histidine-mediated RNA transfer to GDP for unique mRNA capping by vesicular stomatitis virus RNA polymerase Proc. Natl. Acad. Sci. USA, 107 (2010), pp. 3463-3468, 10.1073/pnas.0913083107 View in ScopusGoogle Scholar 49 T. Ogino, A.K. Banerjee The HR motif in the RNA-dependent RNA polyme...
Hendra virus Nipah virus Henipavirus infections antibodies viral B lymphocytes antigen-antibody reactions monoclonal pre-exposure prophylaxis therapy epitopes receptor binding protein molecular structure Introduction Hendra virus (HeV) and Nipah virus (NiV), belonging to the Henipavirus genus in the Paramyx...
Review - Nipah virus: An emerging zoonotic diseaseM SudharsanAM VeerakumarAkiNik Publications
Embodiments of immunogens comprising a recombinant Nipah virus (NiV) F ectodomain trimer stabilized in a prefusion conformation are provided. Also provided are embodiments of immunogens comprising chimeric proteins comprising the recombinant NiV F ectodomain trimer and one or more G ectodomains, a ...
Nipah Virus (NiV) is a re-emerging zoonotic pathogen in the genus Henipavirus of the Paramyxoviridae family of viruses. NiV is endemic to Bangladesh and Malaysia and is highly fatal to both livestock and humans (human case fatality rate = 74.5%). C
Using SAXS and NMR spectroscopy, we herein provide a high-resolution description of the intrinsically disordered N-terminal domain (PNT, aa 1–406) shared by the Nipah virus (NiV) phosphoprotein (P) and V protein, two key players in viral genome replicat