导读:在特发性肺纤维化(Idiopathic Pulmonary Fibrosis, IPF)的治疗中,尼达尼布(Nintedanib)和吡非尼酮(Pirfenidone)是常用的药物。这两种药物都有助于减缓疾病的进展,但它们在治疗效果、副作用和适应症方面存在一些差异。本文将对尼达尼布和吡非尼酮进行比较,了解它们在特发性肺纤维化治疗中的不同特点。 尼达尼布颗粒 ...
今天FDA 同时批准了罗氏的纤维化抑制剂 Pirfenidone(商品名 Esbriet)和 BI 的多蛋白激酶抑制剂 Nintedanib(商品名 Ofev)用于治疗特发性肺纤维化,比预定的 PDUFA 日期提前很多(Esbriet 的 PDUFA 为 11 月 23 日,Ofev 的 PDUFA 为 2015 年 1 月 2 日),显示 FDA 对于重要药物的审批效率。特发性肺纤维化患者...
【新闻事件】:今天FDA同时批准了罗氏的纤维化抑制剂Pirfenidone(商品名Esbriet)和BI的多蛋白激酶抑制剂Nintedanib(商品名Ofev)用于治疗特发性肺纤维化,比预定的PDUFA日期提前很多(Esbriet的PDUFA为11月23日,Ofev的PDUFA为2015年1月2日),显示FDA对于重要药物的审批效率。特发性肺纤维化患者则有望结束无药可用的时代。
Nintedanib and PirfenidoneEver since Louis Hamman and Arnold Rich described the first fatal case of pulmonary fibrosis of unknown etiology more than 80 years ago, the medical community has been challenged by the lack of effective pharmacologic therapy. In 2000, a panel of experts proposed idiopathic...
Pirfenidone and nintedanib for pulmonary fibrosis in clinical practice: Tolerability and adverse drug reactions. Respirology 22: 1171-1178, No. 6, Aug 2017. Available from: URL: http://doi.org/10.1111/resp.13024 -USA Article PubMed Google Scholar Download references Rights and permissions ...
Real-world safety profiles of pirfenidone and nintedanib in idiopathic pulmonary fibrosis patients. Pulmonary Pharmacology and Therapeutics 76: Oct 2022. Available from: URL: http://www.elsevier.com/inca/publications/store/6/2/2/9/3/6/index.htt Download references Rights and permissions Reprints ...
There has been one phase 4 trial that has investigated the combination of Ofev (nintedanib) and Esbriet (pirfenidone) for idiopathic pulmonary fibrosis (IPF) that showed a slightly increased risk of side effects with combination treatment, but the trial was not large enough to make a solid concl...
Nintedanib (BIBF-1120), an orally administered intracellular tyrosine kinase inhibitor (TKI) initially developed as an antitumor agent, has antifibrotic properties and was one of the first drugs (along with the antifibrotic pirfenidone) to be approved for the treatment of IPF in the EU and USA; ...
Respiratory Medicine and Research 79: 100819, May 2021. Available from: URL: https://www.journals.elsevier.com/respiratory-medicine-and-research Download references Rights and permissions Reprints and permissions About this article Cite this article Nintedanib/pirfenidone. Reactions Weekly 1867, 332 (...
Nintedanib/pirfenidone. Reactions Weekly 1833, 306 (2020). https://doi.org/10.1007/s40278-020-87124-9 Download citation Published05 December 2020 Issue DateDecember 2020 DOIhttps://doi.org/10.1007/s40278-020-87124-9 Access this article Log in via an institution Subscribe and save Springer+ ...