by regulating the prescription of the tablet core and the coating film, the velocity of the constant speed of the tablet can be effectively regulated, the stable and lasting effective plasma concentration can be obtained, thus the side effects and drug use of the tablet are reduced, and the ...
Single dose studies in healthy volunteers have shown plasma concentrations of 34 mg/L after a 100mg tablet. These levels were achieved 3.25 hours after administration, and the elimination half-life was 3.3 hours in these subjects. Rectal absorption and elimination was 2 to 3 times more prolonged...
The most serious side effect of nimesulide, however, is hepatotoxicity, or liver damage brought about by toxicity. Chemicals that cause this condition are referred to as hepatotoxins. In a 2003 book titled, the authors identified more than 900 drugs that could increase the risk of hepatotoxicity...
The present invention particularly relates to a pharmaceutical combination in the form of a multilayer oral tablet comprising nimesulide and thiocolchicoside with anti-inflammatory, analgesic and myorelaxant effects.doi:WO2014125085 A1TRKYILMAZ Ali