The Chronic GVHD Consortium was established to validate these criteria, since the scoring system was based on consensus opinion not yet supported by empiric data. This report includes results from the first 298 adult patients (pts) enrolled at 5 centers of this Consortium. Pts were assessed using...
In this study, we found that three grading scales, the NIH eye score, the Japanese dry eye score and the DEWS 2007 score, showed statistically good agreement in the diagnostic rate and the severity of ocular GVHD. The clinical manifestations and pathology of ocular GVHD have been previously st...
Historically, graft-versus-host disease (GVHD) beyond 100 days after hematopoietic cell transplantation (HCT) was called chronic GVHD, even if the clinical manifestations were indistinguishable from acute GVHD. In 2005, the National Institutes of Health (NIH) sponsored a consensus conference that propo...
For both acute and chronic GvHD, a given organ is not considered in the overall GvHD grade if the manifestation is solely due to a non-GvHD cause (e.g. zoster skin infection, chronic obstructive pulmonary disease, steroid myopathy, etc...). In the case of both GvHD and concomitant non-...
Bone Marrow Transplant 2009; 43: P541.Wolff D, Herzberg P, Heussner P, et al. Validation of the NIH criteria of the severity grading of chronic GVHD - results of a prospective German multicenter validation trial. Blood. 2009;114:204 [Abstract]....
The 2005 NIH chronic GVHD (cGVHD) organ severity is based on the assessment of current status regardless of whether abnormalities are due to GVHD. The score assignment does not require knowledge of past manifestations, attribution or whether cGVHD is still active. The aim of this study is to ...
Annals of Hematology /Ayuk F, Veit R, Zabelina T, et al. Prognostic factors for survival of patients with newly diagnosed chronic GVHD according to NIH criteria. Ann Hematol. 2015;94(10):1727-1732.
Because performance of this risk score has not been examined in contemporary patients with chronic GVHD denned by the National Institutes of Health (NIH) criteria and because experience with application of the score to patients at individual centers is limited, we examined performance of the risk ...
InamotoDivisionKimDivisionDennisDivisionD.DivisionStorerDivisionBarryDivisionE.DivisionJoonDivisionHoDivisionEBSCO_AspBloodInamoto Y, Kim DD, Storer BE, et al. Application of CIBMTR risk score to NIH chronic GVHD at individual centers. Blood. 2014;123:453-455....
Quality of Life and Chronic Gvhd Severity According to the NIH Criteria: Results From the Chronic Gvhd Consortium393 Chronic graft-versus-host disease (cGVHD) can negatively impact quality of life (QOL) following allogeneic hematopoietic cell transplantation (HCT). Whether the new NIH cGVHD global ...