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difficult to manufacture ex vivo (for example, in the retina (clinicaltrials.gov identifier NCT03872479) and in the liver (NCT03041324 and NCT04601051)). These studies highlight the great potential of genome editing to improve human health. However, they also underscore the need to address key ...
Edmondson D, Falzon L, Sundquist KJ, Julian J, Meli L, Sumner JA, Kronish IM. A systematic review of the inclusion of mechanisms of action in NIH- funded intervention trials to improve medication adherence. Behav Res Ther. 2018;101:12-9....
Vaxxas’ HD-MAP vaccine delivery platform is advancing toward commercialization, with five successful Phase I clinical trials involving more than 500 participants completed, including a second-generation COVID-19 vaccine candidate, a HD-MAP delivered flu vaccine showing greater immunogenicity than the ...
A systematic review and meta-analysis of randomized clinical trials investigating supplemental calcium and colorectal adenomas generally supported an association of intake with decreased risk over a follow-up period of 3 to 5 years.29 However, 1 randomized chemoprevention trial in patien...
In the setting of clinical trials, response to treatment compares disease burden at specific points in time, usually with regards to a particular treatment. It is based on a number of clinical findings, sometimes including fixed deficits. Classical categories of response are complete response (CR)...
Following the discussions of the first NIH symposium, six major workgroups (WGs) were created to investigate gaps and develop research priorities across six domains: (1) Biology of Coma, (2) Coma Database, (3) Neuroprognostication, (4) Care of Comatose Patients, (5) Early Clinical Trials, ...