半衰期The terminal elimination half life of nifedipine is approximately 2 hours. 清除The total body clearance of nifedipine is 450-700mL/min. 毒理The oral LD in rats is 1022mg/kg and in mice is 202mg/kg.Patients experiencing an overdose may present with hypotension, sinus node dysfunction, at...
dipine were increased in a study in 6 healthy subjects when pretreated with diltiazem; the elimination half-life of nifedipine was prolonged from 2.54 hours to 3.40 hours after pretreatment with diltiazem 30mg daily and to 3.47 hours after 90 mg daily. the effect was probably due to reduced ...
Immediate Release Half Life: 3 hours Reduce dosing in hepatic dysfunction XIII. Drug Interactions Agents that lower Nifedipine levels Carbamazepine Phenobarbital Phenytoin Rifampin St John's Wort Agents that increase Nifedipine levels Clarithromycin Erythromycin Fluconazole Fluoxetine Protease Inhibitors Ketoconaz...
The elimination half-life of nifedipine is apparently dependent upon the dosage form in which it is administered, with half-lives of 6 to 11 hours, 2 to 3.4 hours and 1.3 to 1.8 hours measured after oral tablet, oral capsule and intravenous administration, respectively. The total systemic and...
Half-life2 hours (conventional capsules); 7 hours (Adalat CC extended-release tablets).Special PopulationsElimination may be altered in patients with hepatic impairment. Elimination half-life of 7 hours reported in patients with cirrhosis.Following IV administration, decreased total body clearance in ...
Elimination half-life 2-5 hours (immediate-release) Dosage (Strength) 10 mg, 20 mg capsules (immediate-release); 30 mg, 60 mg, 90 mg tablets (extended-release) Pregnancy Consult a doctor Brands Procardia, Adalat, Nifedical Protein binding 92-98% PubChem CID 4485 MedlinePlus a6840...
also in the form of metabolites. The intrinsic clearance of nifedipine from the plasma ranges from 21 to 37 L/h and the rate of nifedipine elimination is probably dependent on drug metabolising activity and hepatic blood flow. Elimination half-life values of sustained release nifedipine (3.8 to...
Protein binding is 95%, and elimination half-life is approximately 5 hours. Nifedipine is available for oral administration in capsular form. The compound degenerates in the presence of light and moisture, preventing commercially available intravenous preparations. Puncture of the capsule and sublingual...
The maximum dose is 90 mg/day (Adalat CC) or 120 mg/day (Procardia XL). Nifedipine can be taken with or without food. The tablets and capsules should be swallowed whole and not bitten or cut in half. SLIDESHOW How to Lower Blood Pressure: Exercise and Tips See Slideshow Which ...
Co-administration of nifedipine with grapefruit juice resulted in approximately a doubling in nifedipine AUC and Cmax with no change in half-life. The increased plasma concentrations most likely result from inhibition of CYP 3A4 related first-pass metabolism. Avoid ingestion of grapefruit and grapefr...