Nicotinic acid (niacin): new lipid- independent mechanisms of action and therapeutic potentials. Trends Pharmacol Sci 2011; 32:700-707.Lukasova M, Hanson J, Tunaru S and Offermanns S. Nicotinic acid (niacin): new lipid-independent mechanisms of action and therapeutic potentials. Trends Pharmacol...
The general mechanisms of action of hypolipidemic agents are briefly reviewed, taking as example the known effects of nicotinic acid and clofibrate. The ef... F Grande - 《Medicinal Chemistry Advances》 被引量: 0发表: 1981年 Influence of nicotinic acid on metabolism of cholesterol and triglycerid...
1972a Comparison of the capacity of nicotinamide and nicotinic acid to relieve the effects of muscle and cartilage teratogens in developing chick embryos. Dev. Biol., 28: 344- 351. 197213 The effects of the nicotinamide- sensitive ... AI Caplan - 《Journal of Experimental Zoology》 被引量: ...
nicotinic acid是将“菸鹼酸"翻译成 英文。 译文示例:i) 一个国际工业联合会汇报说,该组织已在若干发展中国家内组织了讲习班以便就氯代--碱工业内使用汞晶胞的问题提高认识并交流有关最佳技术和最佳做法的信息 ↔ i) One international industry association reported that it had held workshops in several ...
In a previous study, we demonstrated that IPPA08 did not exert its synergistic effects by inhibiting the activities of detoxification enzymes, such as P450 monooxygenases (P450s), and that it could possess a distinct mode of action (Bao et al., 2016). In this study, we evaluated the ...
We studied the mechanisms and sites of activator actions of 2-[2-(3,4-dichloro-phenyl)-2,3-dihydro-1H-isoindol-5-ylamino]-nicotinic acid [PD307243 (PD)] and 1,3-bis-(2-hydroxy-5-trifluoromethyl-phenyl)-urea [NS1643 (NS)] on the human ether-a-go-go-related gene (hERG) channel ...
For example, there appears to be a signifIcant population of nicotinic receptors in the CAl region of the hippocampus (Freund et al. 1990) that may interact with gamma-aminobutyric acid recep tors. The effects of mecamylamine on inhibiting the transfer of information from short-term or ...
While the etiology of schizophrenia is unknown, imbalances in REVIEW several neurotransmitter systems have been implicated in the pathophysiology of this illness, including structural and functional abnormalities in the dopaminergic, glutamater- gic, g-amino butyric acid (GABA)ergic, and cholinergic ...
This compound is of interest because it may stimulate the release of prostacyclin from the arterial wall; prostacyclin may be derived from HDL phospholipids, unusually rich in arachidonic acid. This observation may offer another clue to the understanding of the mode of arterial protection exerted by...
Ser34, Gln55, Ser146, and Tyr166, which are evolutionarily conserved, were specifically subjected to virtual mutations based on their amino acid properties and found to be highly sensitive in the presence of antagonists by docking. Further, the study was extended using evolutionary trace analysis,...