and any smoking cessation therapy has to deal with both the pharmacological and the psychological dependence on cigarettes. Separating the treatment of these two factors is an approach that has been tried with modest success, for example by satisfying the pharmacological craving with nicotine pills or...
Pharmacological and toxicological actions of the optical isomers of nicotine Ever since the synthesis of nicotine by Pictet and Rotschy in 1904, there has been continued interest in the action of the two enantiomers of nicotine. The natural (S)-nicotine is usually, but not always, more active ...
Nicotine has a multitude of pharmacological and physiological effects, and the responses depend greatly on the dose and rate of absorption. In mammals, the alkaloid targets various receptor subtypes in both the central and the peripheral nervous systems (Maskos, 2007). In general, the initial stimu...
Current pharmacological treatments for nicotine dependence. Trends Pharmacol Sci 2004; 25: 42–8. 94 Biberman R, Neumann R, Katzir I, Gerber Y. A randomized controlled trial of oral selegiline plus nicotine skin patch compared with placebo plus nicotine skin patch for smoking cessation. Addiction...
Pharmacological characterization of recom- binant human neuronal nicotinic acetylcholine receptors h alpha 2 beta 2, h alpha 2 beta 4, h alpha 3 beta 2, h alpha 3 beta 4, h alpha 4 beta 2, h alpha 4 beta 4 and h alpha 7 expressed in Xenopus oocytes. J Pharmacol Exp Ther 280: 346...
People will also be excluded from the trial if they meet any of the following criteria: current users of pharmacological cessation therapies (e.g. NRT, buproprion, clonidine, nortriptyline or varenicline); current clients of another smoking cessation programme or cessation study; they have ...