This study was undertaken to examine the effect of nicotine intravenously (i.v.) on the severity of myocardial ischemic injury following acute coronary artery occlusion in dogs. The myocardial ischemic area was measured by the sum of ST-segment elevations (ST) in epicardial ECG-registrations from...
This study was undertaken to examine the effect of nicotine intravenously (i.v.) on the severity of myocardial ischemic injury following acute coronary artery occlusion in dogs. The myocardial ischemic area was measured by the sum of ST-segment elevations (ST) in epicardial ECG-registrations from...
For example, injection of nicotine into rats produces a biphasic effect on locomotor activity in a dose-dependent manner. First, ataxia is seen, which, at doses larger than 0.8 mg/kg, takes the form of prostration. About 10–20 min later, a stimulant effect can be observed. The ...
The effect of nicotine on a mother or the fetus during labor is unknown. Use In Nursing Mothers Caution should be exercised when NICOTROL NS is administered to nursing mothers. The safety of NICOTROL NS therapy in nursing infants has not been examined. Nicotine passes freely into breast milk;...
Effect of nicotine and ephedrine on the accumulation of 18F-FDG in brown adipose tissue 2007, Journal of Nuclear Medicine A comparative study of the central H-cholinoblocking and NMDA-blocking effects of MK-801, memantine, amantadine, pyrilene, and IEM-1754 in intact rats 2000, Eksperimental'...
Effects of nicotine on arterial endothelium-dependent relaxations mediated by nitric oxide are controversial. Experiments were designed to test the hypothesis that nicotine can directly alter activity of endothelial nitric-oxide synthase (eNOS). NOS from aortic endothelial cells of untreated dogs and recom...
and therefore can still be used to control pests on crops. Rapidly absorbed through the skin, inhalation and dermal exposure to toxic people. Toxic to birds. Young steelhead LC504mg/L, toxic to bees, but there insecticide effect. D. Pulex LC50 of 0.24mg/L. Fish and shellfish toxicity, ...
Tsujimoto A, Nakashima T, Tanino S, Dohi T, Kurogochi Y (1975) Tissue distribution of 3H-nicotine in dogs and rhesus monkeys. Toxicol Appl Pharmacol 32:21–31 Google Scholar Turner DM (1975) Influence of route of administration on metabolism of 14C-nicotine in four species. Xenobiotica 5...
Effect of smokeless tobacco (snus) on smoking and public health in Sweden Objective: To review the evidence on the effects of moist smokeless tobacco (snus) on smoking and ill health in Sweden. Method: Narrative review of publish... J Foulds,L Ramstrom,M Burke and K Fagerstrm - 《Tobacco...
All doses of L-745,870 (0.1–3.0 mg/kg, i.p., 30 min before the start of the session) were administered alone to examine its ability to produce responding on the nicotine-associated lever (ie, to produce a 'nicotine-like' effect). The highest three doses of L-745,870 were ...