and stromal and immune cells in the tumor microenvironment were shown to have significant impact on this tumor cell plasticity71. To test the effect of N2-neutrophil on these processes, we first treated human, mouse primary neutrophils as well as...
Nicotine in tobacco smoke contributes to the pathogenesis of various conditions, such as lung cancer, coronary artery disease and asthma. A decade ago, a seemingly safer alternative to tobacco cigarettes was introduced- the E-cigarette. However, studies have found that E-cigarette smoke (ECS) not...
www.nature.com/scientificreports OPEN received: 19 August 2016 accepted: 16 November 2016 Published: 15 December 2016 Increased Fetal Thymocytes Apoptosis Contributes to Prenatal Nicotine Exposure-induced Th1/Th2 Imbalance in Male Offspring Mice Ting Chen*,You-e Yan*, Sha Liu, Han-xiao ...
摘要: Nicotine contributes to Staphylococcus aureus-induced osteomyelitis.Nicotine induces the Nrf2/Slc7a11 signaling axis and influences osteomyelitis.Erastin can mitigate nicotine's effects via glutamate/glutathione metabolism.关键词: Nicotine Osteomyelitis Macrophage Nrf2/Slc7a11 signaling axis Glutamate/...
Obesity is characterized by chronic low-grade inflammation, which contributes to insulin resistance. Nicotine significantly improves glucose homeostasis and insulin sensitivity in genetically obese and diet-induced obese mice, which is associated with suppressed adipose tissue inflammation. Inflammation that ...
Smoking is associated with lung cancer and has a profound impact on tumor immunity. Nicotine, the addictive and non-carcinogenic smoke component, influences various brain cells and the immune system. However, how long-term use of nicotine affects brain m
Background: Nicotine (Nic), the major component of tobacco products, can induce apoptosis in lung epithelial cells, and the resulting damage contributes to chronic obstructive pulmonary disease. Apoptosis is closely related to autophagy. Resveratrol (Res) can induce autophagy and in...
One of the most devastating health problems of cigarette smoking or smokeless tobacco use in human subjects is vascular damage to vital organs such as the lung, heart, peripheral circulation, and brain. The precise components of cigarette smoke and smokeless tobacco that account for vascular ...
Together, these data suggest that the upregulation of the protein O-GlcNAcylation levels contributes mechanistically to Nic induced EMT and invasion in breast cancer cells. Nic elevates O-GlcNAcylation in breast cancer cells via activation of GFAT and HBP As hyper-O-GlcNAcylation can be supported ...
Nasal and sinus inflammation is common in chronic obstructive pulmonary disease (COPD) and contributes to the decline in lung function [1]. The responses of the bronchial epithelium to cigarette smoke (CS) have been well characterised [2], but effects on the nasal epithelium, also important in...