Oral nicotine bioavailability from moist snuff smokeless tobacco (ST) is influenced by nicotine content, pH, flavors, and tobacco cut. For use in a clinical study testing the effect of pH on nicotine pharmacokinetics, four investigational ST products that differed only in pH were produced. A ...
The amount of nicotine salt, co-crystal, or salt co-crystal can be determined based on the desired nicotine content in the lozenge. Various other substances can be added to the smokeless tobacco compositions comprising the nicotine salts, co-crystals, or salt co-crystals of the present ...
7. The smokeless tobacco product according to claim 1, wherein the sheet has a tobacco content that varies over its entire surface area by at most ±10%. 8. The smokeless tobacco product according to claim 1, wherein the at least one water soluble thermoplastic polymer is contained in an...