The extract was analyzed by liquid chromatography (LC) to obtain the total amount of nicotine in the moist snuff. The content of nicotine in the free-base form was calculated from the Henderson-Hasselbalch equation. In Vivo release of nicotine in STPs In vivo release test of nicotine from ...
The amount of nicotine salt, co-crystal, or salt co-crystal can be determined based on the desired nicotine content in the lozenge. Various other substances can be added to the smokeless tobacco compositions comprising the nicotine salts, co-crystals, or salt co-crystals of the present ...
7. The smokeless tobacco product according to claim 1, wherein the sheet has a tobacco content that varies over its entire surface area by at most ±10%. 8. The smokeless tobacco product according to claim 1, wherein the at least one water soluble thermoplastic polymer is contained in an...