Owing to the high lipid solubility, nicotine can be easily absorbed and accumulated in the fetus after crossing the placental barrier. The thymus is one of the toxic target organs of nicotine, and the development of thymocytes might be disturbed by nicotine. By using the fetal thymus organ ...
Secondly, as it has been demonstrated that APN receptor (AdipoR) phosphorylation may involve in the regulation of APN sensitivity in multiple organs24, and AdipoR1 is abundantly expressed in endothelial cells; therefore, we further investigated the expression of AdipoR1 in aortic tissue. As illustrat...
Regarding the chronic effects of nicotine, we observed no intergroup difference in maternal body weight changes and hemodynamics; however, blood flow to all fetal organs tended to be lower in the nicotine water group than in the water group with significant difference on GD 13.5. The offspring ...
6 by white adipose tissue (WAT), and the activation of a network of pro-inflammatory signaling pathways, including the c-Jun NH2-terminal kinase (JNK) and inhibitor of NF-κB kinase β (IKKβ), which may have local effects on WAT physiology but also systemic effects on other organs [62...
Another reason to consult with your respiratory physician so often is that respiratory problems if remain untreated or ignored over a long time, they can even challenge your survival. Respiratory issues also damage other important organs of a body. So, without thinking anything, whenever you feel ...
21 However, the novel mechanism of MK2 in NPC is still unclear. Cigarette smoke is a major environmental risk factor for the development of many human diseases. Tobacco smoke has a correlation with the development of human malignancies in various human organs.22, 23, 24 Nicotine leads to ...
(central and peripheral nervous system) and non-neuronal tissue. Consequently, nicotine exposure affects numerous systems, including neurological, neuromuscular, cardiovascular, respiratory, immunological and gastrointestinal. The presence of different types of nACh receptors, receptor up-regulation and receptor...
nicotine ameliorated cellular energy metabolism disorders and deferred age-related deterioration and cognitive decline by stimulating neurogenesis, inhibiting neuroinflammation, and protecting organs from oxidative stress and telomere shortening. Collectively, these findings provide evidence for a mechanism by which...
Sometimes, nicotine replacement therapy is recommended as an effective method for smoking cessation during pregnancy5; however, nicotine exposure by itself affects various body organs, which is a crucial issue. Alcohol intake, especially at higher doses is also associated with symptoms such as growth...
solubility, nicotine can be easily absorbed and accumulated in the fetus after crossing the placental barrier. The thymus is one of the toxic target organs of nicotine, and the development of thymocytes might be disturbed by nicotine. By using the fetal thymus organ culture (FTOC), researchers ...