Nicorandil on day 2, while being hemodynamically monitored on an intensive care unit with a pulmonary artery catheter.Through the hemodynamic monitoring a dose dependent, significant reduction of systolic blood pressure was found (6%/9%), while the heart rate increased dose dependently (6%/11%). ...
Background Nicorandil is widely used as a vasodilator for the physiological assessment of coronary arteries because of its usefulness and safety; however, there are no data on its use in peripheral arteries. Aims To identify the utility of nicorandil and its appropriate dose for the physiological ...
Metabolism of nicorandil is mainly by denitration of the molecule into the nicotinamide pathway. About 20% of a dose is excreted in the urine mainly as metabolites Mode of action The coronary vasodilating activity of nicorandil is considered to be the consequence of the increasing cyclic GMP produ...
There is a theoretical contraindication tonicorandilin patients with cardiogenic shock, acute left ventricular failure with low filling pressure, and hypotension. A sublingual dose of 20mg in patients with coronary artery disease and normal left ventricular function was associated with a 12% fall in le...
The expressions of KIR6.1 and KIR6.2 mRNAs were slightly up-regulated by the low dose of nicorandil, whereas the high dose of nicorandil significantly up-regulated those expressions compared to non-treated SHRs.ConclusionsThese data indicate that nicorandil prevents hypertension-related bladder ...
No significant difference was noted in any of the other pharmacokinetic parameters examined in the three groups, not even on comparing values obtained on the first and last days of treatment.The findings suggest that there is no need to change the dose of nicorandil in subjects with different ...
Oral ulceration has many different causes. The association between Nicorandil and oral ulceration is not a new phenomenon. There have been several previous case reports regarding a possible association although none in publications for general dental pra
Decreasing the dose of nicorandil may help with ulcer healing, which is significant since many patients are given nicorandil to treat coronary artery disease and stopping the medicine might result in the recurrence of anginal symptoms.关键词: ulceration ...
assigned to nicorandil discontinued their study drug due to adverse effects, compared with 19.5% in patients assigned to placebo. No study has yet described the potential merit of nicorandil in patients with refractory angina despite classical antianginal drugs administered at maximal tolerable dose.69...
Hence it is concluded that metformin treated along with single/multiple dose treatment with nicorandil has influence on pharmacodynamics of metformin in rats.S. GoliK. E. Kumar