hydrogenationnickelreaction mechanismsAn efficient nickel‐catalyzed asymmetric hydrogenation of N ‐ t Bu‐sulfonyl imines was developed with excellent yields and enantioselectivities using ( R , R )‐QuinoxP* as a chiral ligand. The use of a much lower catalyst loading (0.0095mol%, S/C=10500) ...
The field of asymmetric (transfer) hydrogenation of prochiral olefins has been dominated by noble metal catalysts based on rhodium, ruthenium, and iridium. Herein we report that a simple nickel catalyst is highly active in the transfer hydrogenation using formic acid. Chiral α- and β-amino acid...
The enantioselective reduction of prochiral ketones catalyzed by transition metal complexes, especially asymmetric transfer hydrogenation (ATH) and asymmetric hydrogenation (AH), is one of the most efficient and practical methods for producing chiral alcohols. In both academic laboratories and industrial ...
The 4ca could also smoothly undergo hydrogenation as well as hydroboration-oxidation to yield and product 12 in 90% yield with 92% ee and 1.2:1 dr and enantioenriched silicon-stereogenic hydroxyl-functionalized vinylsilane 13 with 73% yield and 92% ee. Fig. 3: Scale up experiments and ...
Asymmetric transfer hydrogenation of ketones catalyzed by nickel complex with new PNO-type ligands[J]. Zhen Rong Dong~(a,*),Yan Yun Li~a,Shen Luan Yu~a, Guo Song Sun~b,Jing Xing Gao~(a,*) a State Key Laboratory for Physical Chemistry of Solid Surfaces,College of Chemistry and ...
G. The application of monodentate secondary phosphine oxide ligands in rhodium- and iridium-catalyzed asymmetric hydrogenation. Tetrahedron: Asymmetry 2004, 15, 2223-2229; (c) Ackermann, L.; Born, R.; Spatz, J. H.; Althammer, A.; Gschrei, C. Air-stable phosphine oxides as preligands for...
the construction of molecular complexity, a series of late-stage functionalizations of the generated trisubstituted alkene have also been performed despite its large steric hindrance. As illustrated in Fig.5c, fluorinative alkoxylation, electrochemical hydrogenation, photochemical trifluoromethylation, ...
Reductive Arylation of Amides via a Nickel‐Catalyzed Suzuki–Miyaura‐Coupling and Transfer‐Hydrogenation CascadeAngewandte Chemie International Edition (IF 16.1)Timothy B. Boit, Milauni M. Mehta, Junyong Kim, Emma L. Baker, Neil K. Garg Pub Date: 2020-10-07 Nickel‐Catalyzed Cross‐Coupling...
A complementary method to obtain N-acyl enamides using the Heck reaction: extending the substrate scope for asymmetric hydrogenation A method to prepare N-acyl enamides is reported that is complementary to the existing protocols. Heck reaction of a variety of aryl trifluoromethanesulfona... HG Mee...
Transition metal-catalyzed asymmetric hydrogenation is one of the most efficient methods for the preparation of chiral 伪-substituted propionic acids. However, research on this method, employing cleaner earth-abundant metal catalysts, is still insufficient in both academic and industrial contexts. Herein,...