No clinically important difference was demonstrated between paracetamol 3-4 g/day and placebo across all outcomes for knee OA and mixed joint OA (hip/knee). Paracetamol was also found not to be cost-effective due to marginally higher cost of drug acquisition and marginally lower quality adjusted...
Since the publication of its first guidelines the National Institute for Clinical Excellence (NICE) has come under a lot of criticism, particularly with respect to its recommendations in medicine (Bratby, 2001). The first appraisal in the field of surgery was on total hip replacement (THR) and...