Nicardipine hydrochloride capsules are metabolized extensively by the hepatic cytochrome P450 enzymes, CYP2C8, 2D6, and 3A4; less than 1% of intact drug is detected in the urine. Following a radioactive oral dose in solution, 60% of the radioactivity was recovered in the urine and 35% in ...
In monkeys, nisoldipine is extensively metabolized in the liver, however, most of the drug is eliminated renally (76%). In all animal models, the drug is almost completely excreted within 48 hours following oral and intravenous administration Ahr et al (1998a). In other studies, the ...
Nicardipene therapy has been associated with a low rate of transient serum enzyme elevations, but has not been linked convincingly to instances of clinically apparent liver injury with jaundice. View all Drug Classes Cardiovascular Agents Mesh A class of drugs that act by selective inhibition of ...
Nicardipine: a review of its pharmacology and therapeutic efficacy in older patients. Drugs Aging 1993; 3(2): 165–87Frampton JE, Faulds D. Nicardipine: a review of its pharmacology and therapeutic efficacy in older patients. Drug Aging 1993; 3: 165–87...
between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy...
The voltage dependencies of the peak currents before and during the superfusion with nicardipine (10 7 M) were similar although the peak amplitude was suppressed in the presence of the drug. (5) These results suggest that the existence of either (a) two populations of Ca channels that differ...
Adis Drug EvaluationsCardiovascular disordersPreterm labourNicardipine is a water soluble calcium channel antagonist, with predominantly vasodilatory actions. Intravenous (IV) nicardipine (Cardene IV), which demonstrates a relatively rapid onset/offset of action, is used in situations requiring the rapid ...
In this setting nicardipine has been investigated in more than 6000 patients, with improvement of cognitive deterioration in more than 60% of patients treated. The anti-hypertensive activity of nicardipine, its safety and effectiveness in cognitive domain, suggests re-considering this drug in the ...
Nicardipine did not significantly affect heart rate with dose of 1 渭g/kg per minute. No clinical side-effects were observed. Nicardipine could be a first line drug for the treatment of hypertension in paediatric intensive care units.doi:10.1007/BF01953981Treluyer JM...
The compound of the formula has excellent inhibiting activity against II type phospholipase A and is employed as an antiinflammatory drug for various inflammations, an antirheumatic drug, an allergic disease therapeutic agent for asthma, atopic diseases, etc., and that for ischemic blood vessel ...