23. Niacin has been shown to suppress TNF-α-induced release of proinflammatory chemokines thus reducing chemokine MCP-1 (CCL2)-induced recruitment of macrophages into the atherosclerotic lesions18,24,25,26. Interestingly, recentin vitroandin vivostudies have revealed anti-inflammatory...
2,3. The NAD molecule participates in many biochemical transformations, including several reactive centers. Nearly 88% of enzymes that rely on NAD are involved in catabolic pathways. Approximately half of these enzymes are related
It is a coenzyme in the mitochondrial production of ATP, in DNA repair, in secondary messenger signalling related to immunomodulation and inflammation and in the regulation of gene transcription, and a related molecule, NADPH, participates in the reduction of reactive oxygen species [10]. Niacin ...