for NGS analysis is 10–20%. To enrich for the tumor fraction, samples can be macrodissected, or the pathologist can circle the area of the slide enriched for cancer cells to indicate which part to extract. Areas of necrosis should be avoided as ...
NGS testing is already used extensively in oncology, particularly in metastatic cancer, she noted. The technology is used to assess the sequence of DNA in genes from a tumor tissue sample. Numerous genes can be quickly sequenced at the same time at relatively low cost. The results provide info...
[7] Quality Management for Molecular Genetic Testing; Approved Guideline MM20-A [8] Comparison of immunohistochemistry with fluorescence in situ hybridization in determining the human epidermal growth factor receptor 2 status of breast cancer specimens: a multicenter study of 3 149 Chinese patients. C...
[8] Tan A C, Lai G G Y, Tan G S, et al. Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and co...
Recently, the government has granted insurance benefits to next-generation sequencing (NGS) tests for the exclusive diagnosis of cancer lung cancer. However, industry experts say it would be challenging to use the test vigorously in the domestic clinical
[8] Tan A C, Lai G G Y, Tan G S, et al. Utility of incorporating next-generation sequencing (NGS) in an Asian non-small cell lung cancer (NSCLC) population: Incremental yield of actionable alterations and cost-effectiveness analysis[J]. Lung Cancer (Amsterdam, Netherlands), 2020, 139:...
The objective of this review was to summarize the evidence regarding NGS efficacy, while also investigating and collating the cost-effectiveness studies of NGS in the field of cancer research. NGS was also analyzed in terms of subsequent treatment strategy....
It's not designing a new drug, it's taking a drug meant for another purpose and giving it in the right settings to patients with cancer who have this biomarker [detected via] NGS testing. You're going to see a whole area of advancement in real-time. You mentioned cost is a ...
Consequently, MRD detection by NGS has been recommended for clinical trials only. Recently developed, error-corrected NGS technologies have made NGS more attractive for routine MRD estimation. The overall levels of cell-free DNA are also observed to be more in cancer because of the...
With extremely high sensitivity and specificity,it can promote basic and clinical research on tumor gene mutations and reduce the economic cost of detection,which is therefore worthy of wide application in the clinical diagnosis and treatment of patients with lung cancer....